Wei Zhong Leong
Overview
Explore the profile of Wei Zhong Leong including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
8
Citations
269
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
He L, Zhao T, Leong W, Sharda A, Mayerhofer C, Mei S, et al.
Blood
. 2025 Feb;
PMID: 39912669
Differentiation arrest and dependence on oxidative metabolism are features shared among genetically diverse acute myeloid leukemias (AML). A phenotypic CRISPR-Cas9 screen in AML identified dependence on phosphoseryl-tRNA kinase (PSTK), an...
2.
Wang Y, Sharda A, Xu S, van Gastel N, Man C, Choi U, et al.
Cell Metab
. 2021 Mar;
33(5):1027-1041.e8.
PMID: 33770508
Mitochondria have an independent genome (mtDNA) and protein synthesis machinery that coordinately activate for mitochondrial generation. Here, we report that the Krebs cycle intermediate fumarate links metabolism to mitobiogenesis through...
3.
Zhang C, Amanda S, Wang C, Tan T, Ali M, Leong W, et al.
Haematologica
. 2020 May;
106(6):1545-1558.
PMID: 32414855
Aldehyde dehydrogenases (ALDHs) are overexpressed in various types of cancers. One of the ALDH family genes, ALDH1A2, is aberrantly expressed in more than 50% of T-cell acute lymphoblastic leukemia (T-ALL)...
4.
Wong R, Tan T, Amanda S, Ngoc P, Leong W, Tan S, et al.
Blood
. 2020 Jan;
135(12):934-947.
PMID: 31972002
Adult T-cell leukemia/lymphoma (ATL) is a highly aggressive hematological malignancy derived from mature CD4+ T-lymphocytes. Here, we demonstrate the transcriptional regulatory network driven by 2 oncogenic transcription factors, IRF4 and...
5.
Tan S, Leong W, Ngoc P, Tan T, Bertulfo F, Lim M, et al.
Blood
. 2019 May;
134(3):239-251.
PMID: 31076442
The oncogenic transcription factor TAL1 regulates the transcriptional program in T-ALL. ARID5B is one of the critical downstream targets of TAL1, which further activates the oncogenic regulatory circuit in T-ALL...
6.
Leong W, Tan S, Ngoc P, Amanda S, Yam A, Liau W, et al.
Genes Dev
. 2018 Jan;
31(23-24):2343-2360.
PMID: 29326336
The oncogenic transcription factor induces an aberrant transcriptional program in T-cell acute lymphoblastic leukemia (T-ALL) cells. However, the critical factors that are directly activated by TAL1 and contribute to T-ALL...
7.
Wong R, Ngoc P, Leong W, Yam A, Zhang T, Asamitsu K, et al.
Blood
. 2017 Oct;
130(21):2326-2338.
PMID: 28978570
A number of studies have recently demonstrated that super-enhancers, which are large cluster of enhancers typically marked by a high level of acetylation of histone H3 lysine 27 and mediator...
8.
Sanda T, Leong W
Exp Hematol
. 2017 Jun;
53:7-15.
PMID: 28652130
In hematopoietic cell development, the transcriptional program is strictly regulated in a lineage- and stage-specific manner that requires a number of transcription factors to work in a cascade or in...
9.
Chien W, Ding L, Sun Q, Torres-Fernandez L, Tan S, Xiao J, et al.
Oncotarget
. 2014 Jun;
5(13):4881-94.
PMID: 24952679
Endoplasmic reticulum stress from unfolded proteins is associated with the proliferation of pancreatic tumor cells, making the many regulatory molecules of this pathway appealing targets for therapy. The objective of...