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Wataru Nishimura

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Recent Articles
21.
Okamoto K, Komasawa N, Nishihara I, Nishimura W, Minami T
Masui . 2016 Mar; 65(2):172-4. PMID: 27017775
We report a patient with multiple myeloma who developed severe hemostatic dysfunction during spinal fusion surgery. A 74-year-old man presented with lower limb paralysis due to thoracic supine pathological fracture...
22.
Oe S, Miki H, Nishimura W, Noda Y
Cell Struct Funct . 2015 Dec; 41(1):23-31. PMID: 26700412
Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor critical for synaptic plasticity, neuronal development and neurite extension. BDNF mRNA is transported to dendrites and axons, where it is expressed locally....
23.
Nishimura W, Kapoor A, El Khattabi I, Jin W, Yasuda K, Bonner-Weir S, et al.
PLoS One . 2015 Nov; 10(11):e0142286. PMID: 26540252
Early in pancreatic development, epithelial cells of pancreatic buds function as primary multipotent progenitor cells (1°MPC) that specify all three pancreatic cell lineages, i.e., endocrine, acinar and duct. Bipotent "Trunk"...
24.
Nishimura W, Ishibashi N, Eto K, Funahashi N, Udagawa H, Miki H, et al.
J Mol Endocrinol . 2015 Jun; 55(1):31-40. PMID: 26108485
Recent studies suggest that dedifferentiation of pancreatic β-cells is involved in compromised β-cell function in diabetes mellitus. We have previously shown that the promoter activity of MafB, which is expressed...
25.
Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, et al.
Proc Natl Acad Sci U S A . 2015 Jun; 112(27):8332-7. PMID: 26100882
Genetic factors are important determinants of the onset and progression of diabetes mellitus. Numerous susceptibility genes for type 2 diabetes, including potassium voltage-gated channel, KQT-like subfamily Q, member1 (KCNQ1), have...
26.
Hiramoto M, Udagawa H, Watanabe A, Miyazawa K, Ishibashi N, Kawaguchi M, et al.
Int J Mol Med . 2015 May; 36(1):222-30. PMID: 25955334
Although recent genome-wide association studies (GWAS) have been extremely successful, it remains a big challenge to functionally annotate disease‑associated single nucleotide polymorphisms (SNPs), as the majority of these SNPs are...
27.
Fujiwara A, Komasawa N, Nishihara I, Miyazaki S, Tatsumi S, Nishimura W, et al.
J Anesth . 2015 Feb; 29(4):580-4. PMID: 25667122
Background: Anesthesiologists often encounter LMA-ProSeal(®) (ProSeal) insertion difficulty due to its large cuff size. We performed a randomized clinical trial to examine how insertion efficacy and sealing pressure of ProSeal...
28.
Nishimura W, Takahashi S, Yasuda K
Diabetologia . 2014 Dec; 58(3):566-74. PMID: 25500951
Aims/hypothesis: The plasticity of adult somatic cells allows for their dedifferentiation or conversion to different cell types, although the relevance of this to disease remains elusive. Perturbation of beta cell...
29.
Ohzawa H, Miki A, Hozumi Y, Miyazaki C, Sagara Y, Tanaka Y, et al.
Oncol Lett . 2014 Dec; 9(1):119-124. PMID: 25435944
Chemotherapy-induced nausea and vomiting is a serious adverse side-effect of anthracycline-based chemotherapy regimens, in patients with breast cancer. A combination of three drugs, 5-hydroxytryptamine (5-HT) receptor antagonist, aprepitant and dexamethasone,...
30.
Nishimura W, Oishi H, Funahashi N, Fujiwara T, Takahashi S, Yasuda K
Endocr J . 2014 Oct; 62(1):37-51. PMID: 25273397
MafA and MafB are basic leucine zipper transcription factors expressed in mature pancreatic β- and α-cells, respectively. MafA is not only an insulin gene transcription factor but is also critical...