Waseem Sajid
Overview
Explore the profile of Waseem Sajid including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
167
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0
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Recent Articles
1.
Roed N, Viola C, Kristensen O, Schluckebier G, Norrman M, Sajid W, et al.
Nat Commun
. 2018 Sep;
9(1):3860.
PMID: 30242155
The insulin/insulin-like growth factor signalling axis is an evolutionary ancient and highly conserved hormonal system involved in the regulation of metabolism, growth and lifespan in animals. Human insulin is stored...
2.
Post S, Karashchuk G, Wade J, Sajid W, De Meyts P, Tatar M
Front Endocrinol (Lausanne)
. 2018 Jun;
9:245.
PMID: 29892262
Insulin and IGF signaling (IIS) is a complex system that controls diverse processes including growth, development, metabolism, stress responses, and aging. IIS is propagated by eight insulin-like peptides (DILPs), homologs...
3.
Outzen E, Zaki M, Mehryar R, Abdolalizadeh B, Sajid W, Boonen H, et al.
Basic Clin Pharmacol Toxicol
. 2016 Nov;
120(4):335-347.
PMID: 27813367
Angiotensin II (Ang II) might induce pro-inflammatory effects directly in the vascular wall independently of its haemodynamic effects. The aim of our study was to investigate the putative direct pro-inflammatory...
4.
Svendsen A, Winge S, Zimmermann M, Lindvig A, Warzecha C, Sajid W, et al.
Biochem J
. 2013 Sep;
457(1):69-77.
PMID: 24059861
The mechanisms whereby insulin analogues may cause enhanced mitogenicity through activation of either the IR (insulin receptor) or the IGF-IR (insulin-like growth factor 1 receptor) are incompletely understood. We demonstrate...
5.
Metzger F, Sajid W, Saenger S, Staudenmaier C, van der Poel C, Sobottka B, et al.
J Biol Chem
. 2011 Apr;
286(22):19501-10.
PMID: 21460230
Insulin-like growth factor I (IGF-I) has important anabolic and homeostatic functions in tissues like skeletal muscle, and a decline in circulating levels is linked with catabolic conditions. Whereas IGF-I therapies...
6.
Sajid W, Kulahin N, Schluckebier G, Ribel U, Henderson H, Tatar M, et al.
J Biol Chem
. 2010 Oct;
286(1):661-73.
PMID: 20974844
We report the crystal structure of two variants of Drosophila melanogaster insulin-like peptide 5 (DILP5) at a resolution of 1.85 Å. DILP5 shares the basic fold of the insulin peptide...
7.
Sajid W, Holst P, Kiselyov V, Andersen A, Conlon J, Kristensen C, et al.
Biochemistry
. 2009 Oct;
48(47):11283-95.
PMID: 19863112
The insulin from the Atlantic hagfish (Myxine glutinosa) has been one of the most studied insulins from both a structural and a biological viewpoint; however, some aspects of its biology...
8.
Gauguin L, Klaproth B, Sajid W, Andersen A, McNeil K, Forbes B, et al.
J Biol Chem
. 2007 Dec;
283(5):2604-13.
PMID: 18048361
Insulin and the insulin-like growth factors (IGFs) bind with high affinity to their cognate receptor and with lower affinity to the noncognate receptor. The major structural difference between insulin and...
9.
De Meyts P, Palsgaard J, Sajid W, Theede A, Aladdin H
Novartis Found Symp
. 2004 Nov;
262:160-71.
PMID: 15562828
The insulin and IGF-1 receptors are members of the superfamily of receptor tyrosine kinases (RTKs). Many of these have been implicated in human cancers due to amplification, overexpression or somatic...