Wanhua Zhang
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Explore the profile of Wanhua Zhang including associated specialties, affiliations and a list of published articles.
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20
Citations
100
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Recent Articles
1.
Yang L, Yang T, Wen Y, Tang M, Teng Y, Zhang W, et al.
J Med Chem
. 2025 Mar;
68(5):5333-5357.
PMID: 40022722
The application of drugs to regulate abnormal epigenetic changes has become an important means of tumor treatment. In this study, we employed computer-aided design methods to develop a novel deazapurine...
2.
Xiao L, Feng J, Zhang W, Pan J, Wang M, Zhang C, et al.
FEBS J
. 2023 Mar;
290(13):3369-3382.
PMID: 36855792
Autism spectrum disorders (ASD) are associated with the contribution of many prenatal risk factors; in particular, the sex hormone progestin and vitamin D receptor (VDR) are associated with gastrointestinal (GI)...
3.
Yang L, Zhang W, Qiu Q, Su Z, Tang M, Bai P, et al.
J Med Chem
. 2022 Aug;
65(17):11890.
PMID: 35998325
No abstract available.
4.
Zhang W, Yang L, Si W, Tang M, Bai P, Zhu Z, et al.
Bioorg Chem
. 2022 Aug;
128:106053.
PMID: 35964504
A hydroxamic acid based microtubule-destabilizing agent (MDA) SKLB-14b was discovered in this study, which was derived from shortening the linker length of the HDAC6 and microtubule dual-target inhibitor SKLB-23bb. SKLB-14b...
5.
Dai Y, Huang J, Kuang P, Hu Y, Zeng Q, Zhang W, et al.
Am J Cancer Res
. 2022 Jul;
12(6):2817-2832.
PMID: 35812060
Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) is a high-risk disease subtype with a dismal prognosis. Inhibiting BCR-ABL kinase alone is insufficient to eradicate Ph+ALL clones, and alternative BCR-ABL-dependent and -independent...
6.
Xiao L, Wang M, Zhang W, Song Y, Zeng J, Li H, et al.
BMC Neurosci
. 2022 Feb;
23(1):8.
PMID: 35164690
Background: Retinoic acid-related orphan receptor alpha (RORA) has been reported to be suppressed in autistic patients and is associated with autism spectrum disorders (ASD), although the potential role and mechanism...
7.
Yang T, Cui X, Tang M, Qi W, Zhu Z, Shi M, et al.
J Med Chem
. 2022 Feb;
65(4):3151-3172.
PMID: 35113547
In this study, we described a series of 2,8-diazaspiro[4.5]decan-1-one derivatives as selective TYK2/JAK1 inhibitors. Systematic exploration of the structure-activity relationship through the introduction of spirocyclic scaffolds based on the reported...
8.
Yang L, Zhang W, Qiu Q, Su Z, Tang M, Bai P, et al.
J Med Chem
. 2021 Oct;
64(20):15379-15401.
PMID: 34648295
Hydroxamic acid group is one of the characteristic pharmacophores of histone deacetylase (HDAC) inhibitors. But here, we discovered a series of hydroxamic acid-based microtubule destabilizing agents (MDAs), which were derived...
9.
Zhang W, Jang E
PLoS One
. 2021 Aug;
16(8):e0256801.
PMID: 34437635
Minimal residual disease (MRD) appeared to be a potent prognostic indicator in patients with Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL), with potential value in informing individualized treatment decisions....
10.
Zhang W, Kuang P, Liu T
PLoS One
. 2020 Dec;
15(12):e0243657.
PMID: 33338050
BCR-ABL1 fusion gene is the driver mutation of Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL). Although the prognostic value of BCR-ABL1 isoforms in Ph+ ALL patients has been investigated...