Wan-Xiang Li
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Explore the profile of Wan-Xiang Li including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
2179
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Recent Articles
1.
Chen G, Han Q, Li W, Hai R, Ding S
Proc Natl Acad Sci U S A
. 2024 Apr;
121(17):e2321170121.
PMID: 38630724
Global control of infectious diseases depends on the continuous development and deployment of diverse vaccination strategies. Currently available live-attenuated and killed virus vaccines typically take a week or longer to...
2.
Liu S, Han Y, Li W, Ding S
Microbiol Mol Biol Rev
. 2023 Apr;
87(2):e0003522.
PMID: 37052496
Immune recognition of viral genome-derived double-stranded RNA (dsRNA) molecules and their subsequent processing into small interfering RNAs (siRNAs) in plants, invertebrates, and mammals trigger specific antiviral immunity known as antiviral...
3.
Liu S, Chen M, Li R, Li W, Gal-On A, Jia Z, et al.
Nat Commun
. 2022 May;
13(1):2994.
PMID: 35637208
Virus-host coevolution often drives virus immune escape. However, it remains unknown whether natural variations of plant virus resistance are enriched in genes of RNA interference (RNAi) pathway known to confer...
4.
Li W, Ding S
Trends Biochem Sci
. 2022 May;
47(11):978-988.
PMID: 35618579
The antiviral defense directed by the RNAi pathway employs distinct specificity and effector mechanisms compared with other immune responses. The specificity of antiviral RNAi is programmed by siRNAs processed from...
5.
Zhang Y, Xu Y, Dai Y, Li Z, Wang J, Ye Z, et al.
PLoS Pathog
. 2021 Aug;
17(8):e1009790.
PMID: 34343211
The interferon-regulated antiviral responses are essential for the induction of both innate and adaptive immunity in mammals. Production of virus-derived small-interfering RNAs (vsiRNAs) to restrict virus infection by RNA interference...
6.
Han Q, Chen G, Wang J, Jee D, Li W, Lai E, et al.
mBio
. 2020 Aug;
11(4).
PMID: 32753500
Distinct mammalian RNA viruses trigger Dicer-mediated production of virus-derived small-interfering RNAs (vsiRNA) and encode unrelated proteins to suppress vsiRNA biogenesis. However, the mechanism and function of the mammalian RNA interference...
7.
Guo Z, Wang X, Li W, Ding S
Methods Mol Biol
. 2019 Jun;
2028:215-229.
PMID: 31228117
RNA interference (RNAi) acts as a natural defense mechanism against virus infection in plants and animals. Much is known about the antiviral function of the core RNAi pathway components identified...
8.
Ding S, Han Q, Wang J, Li W
Curr Opin Immunol
. 2018 Jul;
54:109-114.
PMID: 30015086
Infection of plants and insects with RNA and DNA viruses triggers Dicer-dependent production of virus-derived small interfering RNAs (vsiRNAs), which subsequently guide specific virus clearance by RNA interference (RNAi). Consistent...
9.
Guo Z, Wang X, Wang Y, Li W, Gal-On A, Ding S
Plant Physiol
. 2017 Nov;
176(2):1587-1597.
PMID: 29184028
Small interfering RNAs (siRNAs) are processed from virus-specific dsRNA to direct antiviral RNA interference (RNAi) in diverse eukaryotic hosts. We have recently performed a sensitized genetic screen in Arabidopsis ()...
10.
Coffman S, Lu J, Guo X, Zhong J, Jiang H, Broitman-Maduro G, et al.
mBio
. 2017 Mar;
8(2).
PMID: 28325765
Dicer enzymes process virus-specific double-stranded RNA (dsRNA) into small interfering RNAs (siRNAs) to initiate specific antiviral defense by related RNA interference (RNAi) pathways in plants, insects, nematodes, and mammals. Antiviral...