Walter M Gregory
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Explore the profile of Walter M Gregory including associated specialties, affiliations and a list of published articles.
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62
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3350
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Recent Articles
11.
Went M, Kinnersley B, Sud A, Johnson D, Weinhold N, Forsti A, et al.
Hum Genomics
. 2019 Aug;
13(1):37.
PMID: 31429796
Background: While genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate causal...
12.
Cook G, Royle K, Pawlyn C, Hockaday A, Shah V, Kaiser M, et al.
Lancet Haematol
. 2019 Feb;
6(3):e154-e166.
PMID: 30738834
Background: Tolerability of treatments for multiple myeloma can depend on the characteristics of the patient being treated. We aimed to develop and validate a risk profile, using routinely collected data,...
13.
Jones J, Weinhold N, Ashby C, Walker B, Wardell C, Pawlyn C, et al.
Haematologica
. 2019 Feb;
104(7):1440-1450.
PMID: 30733268
The emergence of treatment resistant sub-clones is a key feature of relapse in multiple myeloma. Therapeutic attempts to extend remission and prevent relapse include maximizing response and the use of...
14.
Tulotta C, Lefley D, Freeman K, Gregory W, Hanby A, Heath P, et al.
Clin Cancer Res
. 2019 Jan;
25(9):2769-2782.
PMID: 30670488
Purpose: Breast cancer bone metastases are incurable, highlighting the need for new therapeutic targets. After colonizing bone, breast cancer cells remain dormant, until signals from the microenvironment stimulate outgrowth into...
15.
Went M, Sud A, Speedy H, Sunter N, Forsti A, Law P, et al.
Blood Cancer J
. 2019 Jan;
9(1):1.
PMID: 30602759
The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM)...
16.
Jackson G, Davies F, Pawlyn C, Cairns D, Striha A, Collett C, et al.
Lancet Oncol
. 2018 Dec;
20(1):57-73.
PMID: 30559051
Background: Patients with multiple myeloma treated with lenalidomide maintenance therapy have improved progression-free survival, primarily following autologous stem-cell transplantation. A beneficial effect of lenalidomide maintenance therapy on overall survival in...
17.
Shah V, Johnson D, Sherborne A, Ellis S, Aldridge F, Howard-Reeves J, et al.
Blood
. 2018 Oct;
132(23):2465-2469.
PMID: 30373884
Multiple myeloma (MM) is a genetically heterogeneous cancer of bone marrow plasma cells with variable outcome. To assess the prognostic relevance of clonal heterogeneity of copy number, we profiled tumors...
18.
Ubellacker J, Baryawno N, Severe N, DeCristo M, Sceneay J, Hutchinson J, et al.
Cancer Res
. 2018 Aug;
78(18):5300-5314.
PMID: 30065048
The presence of disseminated tumor cells in breast cancer patient bone marrow aspirates predicts decreased recurrence-free survival. Although it is appreciated that physiologic, pathologic, and therapeutic conditions impact hematopoiesis, it...
19.
Royle K, Gregory W, Cairns D, Bell S, Cook G, Owen R, et al.
Br J Haematol
. 2018 Jul;
182(6):816-829.
PMID: 29984830
In the Medical Research Council (MRC) Myeloma IX trial (ISRCTN684564111) patients were randomised to sodium clodronate or zoledronic acid and induction treatment: cyclophosphamide, vincristine, doxorubicin and dexamethasone (CVAD) or cyclophosphamide,...
20.
Johnson D, Lenive O, Mitchell J, Jackson G, Owen R, Drayson M, et al.
Blood
. 2017 Aug;
130(14):1639-1643.
PMID: 28827410
Recent studies suggest that the evolutionary history of a cancer is important in forecasting clinical outlook. To gain insight into the clonal dynamics of multiple myeloma (MM) and its possible...