Walter E Finkbeiner
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Explore the profile of Walter E Finkbeiner including associated specialties, affiliations and a list of published articles.
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45
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1704
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Recent Articles
1.
Leung C, Tang M, Finkbeiner W, Johansson M, Denlinger L, Jarjour N, et al.
Am J Respir Crit Care Med
. 2025 Feb;
PMID: 39998476
Background: A subset of asthma patients have airway pathology characterized by a thickened subepithelial basement membrane zone ("BMZ-thick asthma"). Objectives: To characterize the clinical features of BMZ-thick asthma and to...
2.
Koh K, Bonser L, Eckalbar W, Yizhar-Barnea O, Shen J, Zeng X, et al.
Cell Genom
. 2023 Feb;
3(1):100229.
PMID: 36777184
Epithelial responses to the cytokine interleukin-13 (IL-13) cause airway obstruction in asthma. Here we utilized multiple genomic techniques to identify IL-13-responsive regulatory elements in bronchial epithelial cells and used these...
3.
Boecking C, Walentek P, Zlock L, Sun D, Wolters P, Ishikawa H, et al.
Am J Physiol Lung Cell Mol Physiol
. 2022 Jan;
322(3):L420-L437.
PMID: 35080188
Organoids, which are self-organizing three-dimensional cultures, provide models that replicate specific cellular components of native tissues or facets of organ complexity. We describe a simple method to generate organoid cultures...
4.
Bonser L, Eckalbar W, Rodriguez L, Shen J, Koh K, Ghias K, et al.
Am J Respir Cell Mol Biol
. 2022 Jan;
66(4):391-401.
PMID: 34982656
Asthma is associated with chronic changes in the airway epithelium, a key target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many epithelial changes, including goblet cell metaplasia, are driven...
5.
Siddiqui S, Johansson K, Joo A, Bonser L, Koh K, Le Tonqueze O, et al.
JCI Insight
. 2021 Mar;
6(5).
PMID: 33682796
IL-13-induced goblet cell metaplasia contributes to airway remodeling and pathological mucus hypersecretion in asthma. miRNAs are potent modulators of cellular responses, but their role in mucus regulation is largely unexplored....
6.
Bonser L, Eckalbar W, Rodriguez L, Shen J, Koh K, Zlock L, et al.
bioRxiv
. 2021 Mar;
PMID: 33655249
Rationale: Asthma is associated with chronic changes in the airway epithelium, a key target of SARS-CoV-2. Many epithelial changes are driven by the type 2 cytokine IL-13, but the effects...
7.
Bonser L, Koh K, Johansson K, Choksi S, Cheng D, Liu L, et al.
Am J Respir Cell Mol Biol
. 2020 Nov;
64(3):308-317.
PMID: 33196316
The human airway epithelium is essential in homeostasis, and epithelial dysfunction contributes to chronic airway disease. Development of flow-cytometric methods to characterize subsets of airway epithelial cells will enable further...
8.
Park J, Shrivastava A, Zhang C, Pollok B, Finkbeiner W, Gibb E, et al.
Front Pediatr
. 2020 Oct;
8:536.
PMID: 33014932
Functional profiling of CFTR-directed therapeutics offers the potential to provide significant benefits to young people with cystic fibrosis (CF). However, the development of 2D airway epithelial cell models for individual...
9.
Phuan P, Haggie P, Tan J, Rivera A, Finkbeiner W, Nielson D, et al.
J Cyst Fibros
. 2020 Jul;
20(3):452-459.
PMID: 32674984
Background: The c.3700A>G mutation, a rare cystic fibrosis (CF)-causing CFTR mutation found mainly in the Middle East, produces full-length transcript encoding a missense mutation (I1234V-CFTR), and a cryptic splice site...
10.
Phuan P, Tan J, Rivera A, Zlock L, Nielson D, Finkbeiner W, et al.
Sci Rep
. 2019 Nov;
9(1):17640.
PMID: 31776420
Available CFTR modulators provide no therapeutic benefit for cystic fibrosis (CF) caused by many loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, including N1303K. We previously...