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Wai Tat Wong

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Recent Articles
11.
So C, Ling L, Wong W, Zhang J, Ho C, Ng P, et al.
Thorax . 2022 Aug; 78(7):674-681. PMID: 35981883
Background: Tuberculosis (TB) is a preventable and curable disease, but mortality remains high among those who develop sepsis and critical illness from TB. Methods: This was a population-based, multicentre retrospective...
12.
Kumta N, Heffernan A, Cotta M, Wallis S, Livermore A, Starr T, et al.
Antimicrob Agents Chemother . 2022 Jul; 66(8):e0014222. PMID: 35862757
Morbidity and mortality related to ventriculitis in neurocritical care patients remain high. Antibiotic dose optimization may improve therapeutic outcomes. In this study, a population pharmacokinetic model of meropenem in infected...
13.
Ling L, Chen Z, Lui G, Wong C, Wong W, Ng R, et al.
Front Immunol . 2021 Dec; 12:763292. PMID: 34938289
The cytokine release syndrome has been proposed as the driver of inflammation in coronavirus disease 2019 (COVID-19). However, studies on longitudinal cytokine profiles in patients across the whole severity spectrum...
14.
Gullapalli N, Lim Z, Ramanathan K, Bihari S, Haji J, Shekar K, et al.
Aust Crit Care . 2021 May; 35(1):5-12. PMID: 33965312
Background: Personal-protective equipment (PPE)-preparedness, defined as adherence to guidelines, healthcare worker (HCW) training, procuring PPE stocks and responding appropriately to suspected cases, is crucial to prevent HCW-infections. Objectives: To perform...
15.
Ling L, Ho C, Ng P, Chan K, Shum H, Chan C, et al.
J Intensive Care . 2021 Jan; 9(1):2. PMID: 33407925
Background: Globally, mortality rates of patients admitted to the intensive care unit (ICU) have decreased over the last two decades. However, evaluations of the temporal trends in the characteristics and...
16.
Rajamani A, Subramaniam A, Shekar K, Haji J, Luo J, Bihari S, et al.
Aust Crit Care . 2020 Nov; 34(2):135-141. PMID: 33214027
Background: There has been a surge in coronavirus disease 2019 admissions to intensive care units (ICUs) in Asia-Pacific countries. Because ICU healthcare workers are exposed to aerosol-generating procedures, ensuring optimal...
17.
Kumta N, Roberts J, Lipman J, Wong W, Joynt G, Cotta M
Antimicrob Agents Chemother . 2020 Oct; 65(1). PMID: 33077649
Ventriculostomy-associated infections in critically ill patients remain therapeutically challenging because of drug- and disease-related factors that contribute to suboptimal antibiotic concentrations in cerebrospinal fluid. Optimal antibiotic dosing for the treatment...
18.
Wai Lai V, Ho K, Wong W, Leung P, Gomersall C, Underwood M, et al.
BMJ Qual Saf . 2020 Apr; 30(3):228-235. PMID: 32321777
Background: Preoperative education may help participants to psychologically prepare themselves for surgery, but the outcomes of such preparation have rarely been assessed in patients requiring postoperative care in the intensive...
19.
Tenney J, Yip J, Lee R, Wong B, Hung K, Lam R, et al.
J Cardiol . 2020 Feb; 76(1):9-13. PMID: 32107069
Background: Early medication administration in cardiac arrest improves outcomes. The primary objective was to evaluate the association between epinephrine administration in in-hospital cardiac arrest (IHCA) patients with non-shockable rhythm and...
20.
Ho J, Chan H, Liang Y, Liu X, Zhang L, Li Q, et al.
Crit Care . 2020 Feb; 24(1):47. PMID: 32041659
Objectives: The intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation. Previous studies...