Wai Lee Wong
Overview
Explore the profile of Wai Lee Wong including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
12
Citations
995
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Young J, Nguyen A, Qiu Z, Ying Y, Gao X, Reed C, et al.
J Immunol Methods
. 2015 May;
424:91-9.
PMID: 26009247
During drug development, measurement of suitable pharmacodynamic biomarkers is key to establishing in vivo drug activity. Binding of monoclonal antibody (mAb) therapeutics to soluble target proteins often results in elevated...
2.
Shen B, Xu K, Liu L, Raab H, Bhakta S, Kenrick M, et al.
Nat Biotechnol
. 2012 Jan;
30(2):184-9.
PMID: 22267010
The reactive thiol in cysteine is used for coupling maleimide linkers in the generation of antibody conjugates. To assess the impact of the conjugation site, we engineered cysteines into a...
3.
Lu Y, Vernes J, Chiang N, Ou Q, Ding J, Adams C, et al.
J Immunol Methods
. 2010 Dec;
365(1-2):132-41.
PMID: 21185301
Clinical response to the anti-CD20 antibody rituximab has been demonstrated to correlate with the polymorphism in the FcγRIIIa receptor where patients homozygous for the higher affinity V158 allotype showed a...
4.
Young J, Yu X, Wolslegel K, Nguyen A, Kung C, Chiang E, et al.
Cytokine
. 2010 Apr;
51(1):78-86.
PMID: 20356761
Tumor necrosis factor-superfamily (TNF-SF) members, lymphotoxin (LT)-alpha and LTbeta, are proinflammatory cytokines associated with pathology in rheumatoid arthritis. LTalpha3 homotrimers are secreted, whereas LTalpha(1)beta(2) heterotrimers are expressed on the surface...
5.
Lu Y, Xiang H, Liu P, Tong R, Watts R, Koch A, et al.
MAbs
. 2010 Jan;
1(4):364-9.
PMID: 20068394
Neuropilin-1 (NRP1) acts as a co-receptor for class 3 semaphorins and vascular endothelial growth factor and is an attractive angiogenesis target for cancer therapy. In addition to the transmembrane form,...
6.
Junutula J, Raab H, Clark S, Bhakta S, Leipold D, Weir S, et al.
Nat Biotechnol
. 2008 Jul;
26(8):925-32.
PMID: 18641636
Antibody-drug conjugates enhance the antitumor effects of antibodies and reduce adverse systemic effects of potent cytotoxic drugs. However, conventional drug conjugation strategies yield heterogenous conjugates with relatively narrow therapeutic index...
7.
Gutierrez J, Konecny G, Hong K, Burges A, Henry T, Lambiase P, et al.
Clin Chem
. 2008 Mar;
54(3):597-601.
PMID: 18310147
Background: Vascular endothelial growth factor (VEGF), which affects tumor angiogenesis, is expressed as different splice variants, including the major isoforms VEGF(165) and VEGF(121), and can be cleaved by plasmin to...
8.
Lu Y, Wong W, Meng Y
J Immunol Methods
. 2006 Jul;
314(1-2):74-9.
PMID: 16814318
A cell-based ELISA using suspension WIL2 cells in 96-well format was previously developed for measuring relative binding affinities of humanized anti-CD20 variants. We further developed a new cell-binding assay that...
9.
Zhang Y, Yeh S, Appleton B, Held H, Kausalya P, Phua D, et al.
J Biol Chem
. 2006 Jun;
281(31):22299-22311.
PMID: 16737968
We present a detailed comparative analysis of the PDZ domains of the human LAP proteins Erbin, Densin-180, and Scribble and the MAGUK ZO-1. Phage-displayed peptide libraries and in vitro affinity...
10.
Hong K, Presta L, Lu Y, Penn A, Adams C, Chuntharapai A, et al.
J Immunol Methods
. 2004 Dec;
294(1-2):189-97.
PMID: 15604027
Rituxan, a chimeric anti-CD20 antibody, has been used for treating non-Hodgkin's lymphoma and some autoimmune diseases. However, a humanized anti-CD20 antibody is desirable for long-term treatment of autoimmune diseases. CD20...