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Wai-Shiu Fred Wong

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Articles 6
Citations 235
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Recent Articles
1.
Dagnachew Y, Lim H, Wupeng L, Lim S, Lim S, Thiam C, et al.
Front Immunol . 2025 Jan; 15():1493395. PMID: 39830508
Introduction: Collagen is essential for maintaining lung structure and function and its remodeling has been associated with respiratory diseases including chronic obstructive pulmonary disease (COPD). However, the cellular mechanisms driving...
2.
Tan W, Liao W, Zhou S, Mei D, Wong W
Curr Opin Pharmacol . 2017 Dec; 40:9-17. PMID: 29288933
The renin-angiotensin system (RAS) plays a major role in regulating electrolyte balance and blood pressure. RAS has also been implicated in the regulation of inflammation, proliferation and fibrosis in pulmonary...
3.
Liao W, Dong J, Peh H, Tan L, Lim K, Li L, et al.
Molecules . 2017 Jan; 22(1). PMID: 28106744
Inhaled oligonucleotide is an emerging therapeutic modality for various common respiratory diseases, including obstructive airway diseases like asthma and chronic obstructive pulmonary disease (COPD) and restrictive airway diseases like idiopathic...
4.
Venugopal S, Chen M, Liao W, Er S, Wong W, Ge R
Cardiovasc Res . 2015 May; 107(1):131-42. PMID: 25952901
Aims: Isthmin (ISM) is a recently identified 60 kDa secreted angiogenesis inhibitor. Two cell-surface receptors for ISM have been defined, the high-affinity glucose-regulated protein 78 kDa (GRP78) and the low-affinity...
5.
Nguyen V, Loh X, Wijaya H, Wang J, Lin Q, Lam Y, et al.
J Nat Prod . 2015 Jan; 78(2):208-17. PMID: 25615020
Andrographolide (1) is a diterpenoid lactone with an α,β-unsaturated lactone group that inhibits NF-κB DNA binding. Andrographolide reacts with the nucleophilic Cys62 of NF-κB p50 through a Michael addition at...
6.
Yang N, Tan S, Ng S, Shi Y, Zhou J, Tan K, et al.
J Biol Chem . 2014 Oct; 289(48):33425-41. PMID: 25305013
Artesunate (ART) is an anti-malaria drug that has been shown to exhibit anti-tumor activity, and functional lysosomes are reported to be required for ART-induced cancer cell death, whereas the underlying...
7.
Shen J, Tai Y, Zhou J, Wong C, Cheang P, Wong W, et al.
Exp Hematol . 2007 Jan; 35(1):75-83. PMID: 17198876
We investigated the antiproliferative effect of genistein, and its antileukemia effect in combination with cytosine arabinoside (ara-C) in acute myeloid leukemia (AML). Optimal dosage of genistein as single agent and...