W Winn Chatham
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Explore the profile of W Winn Chatham including associated specialties, affiliations and a list of published articles.
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42
Citations
3833
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Recent Articles
1.
Lu C, Liu S, Gao M, Rubio J, Chatham W, Hsu H, et al.
Clin Immunol
. 2025 Mar;
:110472.
PMID: 40068727
TLR7 stimulation of T-betCD11cIgDCD27 double-negative 2 (DN2) B cells is crucial for autoantibody formation in systemic lupus erythematosus (SLE). Here, we show that administration of IL-4 for five weeks significantly...
2.
Chatham W
Adv Exp Med Biol
. 2024 Aug;
1448:399-408.
PMID: 39117829
Patients with established rheumatic disorders may develop complications of macrophage activation syndrome due to severe flares of the underlying disease (adult-onset Still's disease, SLE); however, in most other rheumatic disorders,...
3.
Alduraibi F, Sullivan K, Chatham W, Hsu H, Mountz J
Clin Immunol
. 2023 Jan;
247:109239.
PMID: 36682593
T-helper cytokines interferon gamma (IFNɣ), interleukin 17 (IL-17) and IL-10 impact systemic lupus erythematosus (SLE) directly and indirectly via modulation of autoAb production. We determined the separate and combined effects...
4.
Cron R, Goyal G, Chatham W
Annu Rev Med
. 2022 Oct;
74:321-337.
PMID: 36228171
Cytokine storm syndrome (CSS), which is frequently fatal, has garnered increased attention with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions associated with multiorgan system failure can be lumped...
5.
Gao M, Liu S, Chatham W, Mountz J, Hsu H
J Immunol
. 2022 Sep;
209(8):1513-1522.
PMID: 36165181
Activated naive (aNAV) B cells have been shown to be the precursor of the CD11cT-bet IgDCD27 double-negative (DN)2 or atypical memory (aMEM) B cells in systemic lupus erythematosus (SLE). To...
6.
Tran T, Muhammad H, Chatham W, Crowe D, Gaffo A
Am J Med Sci
. 2022 May;
364(4):466-471.
PMID: 35490705
Necrotizing sarcoid granulomatosis (NSG) is a rare disease that shares similarities with pulmonary vasculitides and sarcoidosis. This is a report of two cases of NSG with a review of literature....
7.
Lupus nephritis correlates with B cell interferon-β, anti-Smith, and anti-DNA: a retrospective study
Alduraibi F, Fatima H, Hamilton J, Chatham W, Hsu H, Mountz J
Arthritis Res Ther
. 2022 Apr;
24(1):87.
PMID: 35436902
Background: In systemic lupus erythematosus (SLE), detection of interferon-β (IFNβ) in B cells was found to be most prominent in patients with high anti-Smith (Sm) and renal disease, but a...
8.
Cron R, Caricchio R, Chatham W
Nat Med
. 2021 Sep;
27(10):1674-1675.
PMID: 34480126
No abstract available.
9.
Chatham W, Furie R, Saxena A, Brohawn P, Schwetje E, Abreu G, et al.
Arthritis Rheumatol
. 2020 Nov;
73(5):816-825.
PMID: 33225631
Objective: To investigate long-term safety and tolerability of anifrolumab, a human monoclonal antibody to the type I interferon (IFN) receptor subunit 1, in patients with moderate-to-severe systemic lupus erythematosus (SLE)....
10.
Atisha-Fregoso Y, Malkiel S, Harris K, Byron M, Ding L, Kanaparthi S, et al.
Arthritis Rheumatol
. 2020 Aug;
73(1):121-131.
PMID: 32755035
Objective: To assess the safety, mechanism of action, and preliminary efficacy of rituximab followed by belimumab in the treatment of refractory lupus nephritis (LN). Methods: In a multicenter, randomized, open-label...