W Siems
Overview
Explore the profile of W Siems including associated specialties, affiliations and a list of published articles.
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Articles
84
Citations
395
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Recent Articles
1.
Grune T, Scherat T, Behrend H, Conradi E, Brenke R, Siems W
Phytomedicine
. 2012 Dec;
2(3):205-7.
PMID: 23194617
The influence of daily application of coated garlic powder tablets (900 mg with an alliin content of 1.3% and an allicin content of 0.6%) on serum levels of malondialdehyde (MDA)...
2.
Gueraud F, Atalay M, Bresgen N, Cipak A, Eckl P, Huc L, et al.
Free Radic Res
. 2010 Sep;
44(10):1098-124.
PMID: 20836659
Oxidative stress and resulting lipid peroxidation is involved in various and numerous pathological states including inflammation, atherosclerosis, neurodegenerative diseases and cancer. This review is focused on recent advances concerning the...
3.
Salerno C, Capuozzo E, Crifo C, Siems W
Biochim Biophys Acta
. 2007 Jul;
1772(9):1052-6.
PMID: 17618090
It has been found that beta-carotene cleavage products (CarCP), besides having mutagenic and toxic effects on mitochondria due to their prooxidative properties, also initiate spontaneous apoptosis of human neutrophils. Therefore,...
4.
Alija A, Bresgen N, Sommerburg O, Langhans C, Siems W, Eckl P
Carcinogenesis
. 2006 Jan;
27(6):1128-33.
PMID: 16418177
Since it has to be expected that individuals exposed to oxidative stress who take supplements of beta-carotene are simultaneously exposed to both beta-carotene cleavage products (CPs) and oxidative stress, and...
5.
Salerno C, Crifo C, Capuozzo E, Sommerburg O, Langhans C, Siems W
Biofactors
. 2006 Jan;
24(1-4):185-92.
PMID: 16403979
Human neutrophils are short-lived cells that play important roles in host defense and acute inflammation by releasing hydrolytic and cytotoxic proteins and reactive oxygen derivatives. Apoptosis, a physiological mechanism for...
6.
Alija A, Bresgen N, Sommerburg O, Langhans C, Siems W, Eckl P
Biofactors
. 2006 Jan;
24(1-4):159-63.
PMID: 16403976
Free radical attack on beta-carotene results in the formation of high amounts of cleavage products with prooxidant activities towards subcellular organelles such as mitochondria, a finding which could provide an...
7.
Crifo C, Capuozzo E, Siems W, Salerno C
Biofactors
. 2006 Jan;
24(1-4):137-40.
PMID: 16403973
4-Hydroxy-2,3-trans-nonenal (HNE), a major lipid peroxidation product, has been shown to react with specific amino acid residues of proteins and alter their function. In vitro exposure of erythrocyte ghosts and...
8.
Crifo C, Siems W, Soro S, Salerno C
Biofactors
. 2006 Jan;
24(1-4):131-6.
PMID: 16403972
Adenylosuccinate lyase is an enzyme of fumarase superfamily that participates in the purine biosynthetic pathway, catalysing the nonhydrolytic cleavage of succinyl groups from SAICA ribotide and adenylosuccinate. Enzyme defects are...
9.
Alija A, Bresgen N, Sommerburg O, Siems W, Eckl P
Carcinogenesis
. 2003 Dec;
25(5):827-31.
PMID: 14688018
According to Siems and colleagues, free radical attack on beta-carotene results in the formation of high amounts of cleavage products with prooxidant activities towards subcellular organelles such as mitochondria. This...
10.
Siems W, Capuozzo E, LUCANO A, Salerno C, Crifo C
Life Sci
. 2003 Sep;
73(20):2583-90.
PMID: 12967682
Lipid peroxidation results in release of 4-hydroxy-2,3-trans-nonenal (HNE), which is known to conjugate to specific amino acids of proteins and may alter their function. The effect of HNE on the...