W S Pear
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Explore the profile of W S Pear including associated specialties, affiliations and a list of published articles.
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28
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2641
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Recent Articles
1.
Pear W, Scott M, Nolan G
Methods Mol Med
. 2014 Feb;
7:41-57.
PMID: 24493417
Retroviral gene transfer is presently one of the most powerful techniques for introducing stably heritable genetic material into mammalian cells (reviewed in ref. 1). One serious drawback of this technique,...
2.
Pajcini K, Speck N, Pear W
Leukemia
. 2011 Jun;
25(10):1525-32.
PMID: 21647159
Notch is a crucial cell signaling pathway in metazoan development. By means of cell-cell interactions, Notch signaling regulates cellular identity, proliferation, differentiation and apoptosis. Within the last decade, numerous studies...
3.
Bannish G, Fuentes-Panana E, Cambier J, Pear W, Monroe J
J Exp Med
. 2001 Dec;
194(11):1583-96.
PMID: 11733573
Signal transduction through the B cell antigen receptor (BCR) is determined by a balance of positive and negative regulators. This balance is shifted by aggregation that results from binding to...
4.
Aster J, Pear W
Curr Opin Hematol
. 2001 Sep;
8(4):237-44.
PMID: 11561162
Mammalian Notch homologs were first identified from the involvement of Notch1 in a recurrent chromosomal translocation in a subset of human T-cell leukemias. The effect of the translocation was twofold:...
5.
Di Cristofano A, Niki M, Zhao M, Karnell F, Clarkson B, Pear W, et al.
J Exp Med
. 2001 Aug;
194(3):275-84.
PMID: 11489947
p62(dok) has been identified as a substrate of many oncogenic tyrosine kinases such as the chronic myelogenous leukemia (CML) chimeric p210(bcr-abl) oncoprotein. It is also phosphorylated upon activation of many...
6.
Izon D, Rudd K, DEMUTH W, Pear W, Clendenin C, Lindsley R, et al.
J Immunol
. 2001 Jul;
167(3):1387-92.
PMID: 11466357
B cells and dendritic cells (DCs) each develop from poorly described progenitor cells in the bone marrow (BM). Although a subset of DCs has been proposed to arise from lymphoid...
7.
Allman D, Karnell F, Punt J, Bakkour S, Xu L, Myung P, et al.
J Exp Med
. 2001 Jul;
194(1):99-106.
PMID: 11435476
Notch1 signaling is required for T cell development. We have previously demonstrated that expression of a dominant active Notch1 (ICN1) transgene in hematopoietic stem cells (HSCs) leads to thymic-independent development...
8.
Izon D, Punt J, Xu L, Karnell F, Allman D, Myung P, et al.
Immunity
. 2001 Apr;
14(3):253-64.
PMID: 11290335
Notch signaling regulates cell fate decisions in multiple lineages. We demonstrate in this report that retroviral expression of activated Notch1 in mouse thymocytes abrogates differentiation of immature CD4+CD8+ thymocytes into...
9.
Zhang X, Wong R, Hao S, Pear W, Ren R
Blood
. 2001 Jan;
97(1):277-87.
PMID: 11133772
Bcr-Abl plays a critical role in the pathogenesis of chronic myelogenous leukemia (CML). It was previously shown that expression of Bcr-Abl in bone marrow cells by retroviral transduction efficiently induces...
10.
Varnum-Finney B, Xu L, Brashem-Stein C, Nourigat C, Flowers D, Bakkour S, et al.
Nat Med
. 2000 Nov;
6(11):1278-81.
PMID: 11062542
Hematopoietic stem cells give rise to progeny that either self-renew in an undifferentiated state or lose self-renewal capabilities and commit to lymphoid or myeloid lineages. Here we evaluated whether hematopoietic...