W N Hittelman
Overview
Explore the profile of W N Hittelman including associated specialties, affiliations and a list of published articles.
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152
Citations
2733
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Recent Articles
1.
Cao Y, Marks J, Liu Z, Cheung L, Hittelman W, Rosenblum M
Oncogene
. 2013 Feb;
33(4):429-39.
PMID: 23376850
Targeted therapeutics are potential therapeutic agents because of their selectivity and efficacy against tumors resistant to conventional therapy. The goal of this study was to determine the comparative activity of...
2.
Hittelman W
Ann N Y Acad Sci
. 2002 Jan;
952:1-12.
PMID: 11795428
Epithelial tumors develop through a multistep process driven by genomic instability frequently associated with etiologic agents such as prolonged tobacco smoke exposure or human papilloma virus (HPV) infection. The purpose...
3.
Follen M, Atkinson E, Schottenfeld D, Malpica A, West L, Lippman S, et al.
Clin Cancer Res
. 2001 Nov;
7(11):3356-65.
PMID: 11705848
Purpose: Previous trials of topical trans-retinoic acid treatment of cervical intraepithelial neoplasia (CIN) grades 2 and 3 led to a statistically significant regression of CIN 2, but not CIN 3....
4.
Papadimitrakopoulou V, Izzo J, Mao L, Keck J, Hamilton D, Shin D, et al.
Clin Cancer Res
. 2001 Oct;
7(10):3127-34.
PMID: 11595705
Purpose: To better understand the role of G(1)-S transition regulator abnormalities in the pathogenesis of advanced premalignant lesions of the upper aerodigestive tract and the biological effects of chemoprevention, we...
5.
Soria J, Moon C, Wang L, Hittelman W, Jang S, Sun S, et al.
J Natl Cancer Inst
. 2001 Aug;
93(16):1257-63.
PMID: 11504771
Background: Telomerase activation plays a critical role in tumorigenesis. To determine the role of telomerase in early lung carcinogenesis and as a potential biomarker in chemoprevention trials, we analyzed the...
6.
Lee J, Liu D, Lee J, Kurie J, Khuri F, Ibarguen H, et al.
J Natl Cancer Inst
. 2001 Jul;
93(14):1081-8.
PMID: 11459869
Background: Lung cancer risk remains elevated for many years after quitting smoking. To assess using proliferation indices in bronchial tissues as an intermediate endpoint biomarker in lung cancer chemoprevention trials,...
7.
Shin D, Charuruks N, Lippman S, Lee J, Ro J, Hong W, et al.
Cancer Epidemiol Biomarkers Prev
. 2001 Jun;
10(6):603-9.
PMID: 11401909
Head and neck cancer develops in a multistep process and is associated with increasing frequencies of p53 alterations and with increasing genomic instability. To study the relationship of p53 alterations...
8.
Kim J, Shin D, El-Naggar A, Lee J, Corrales C, Lippman S, et al.
Cancer Epidemiol Biomarkers Prev
. 2001 Apr;
10(4):319-25.
PMID: 11319171
Head and neck tumorigenesis has been postulated to represent a multistep process driven by the accumulation of carcinogen-induced genetic changes throughout the exposed tissue field. To better explore this genetic...
9.
Khuri F, Lee J, Lippman S, Lee J, Kalapurakal S, Yu R, et al.
Cancer Epidemiol Biomarkers Prev
. 2001 Apr;
10(4):311-8.
PMID: 11319170
Clinical chemoprevention trials seek to intervene in the carcinogenic process to suppress, reverse, or delay the development of invasive cancer. Dysregulated cell growth is a hallmark of epithelial carcinogenesis, and...
10.
Hoque A, Lippman S, Boiko I, Atkinson E, Sneige N, Sahin A, et al.
Cancer Epidemiol Biomarkers Prev
. 2001 Apr;
10(3):249-59.
PMID: 11303595
Clinical management of ductal carcinoma in situ (DCIS) remains a challenge because significant proportions of patients experience recurrence after conservative surgical treatment. Unfortunately, it is difficult to prospectively identify, using...