W M Maniara
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Explore the profile of W M Maniara including associated specialties, affiliations and a list of published articles.
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10
Citations
30
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Recent Articles
1.
Bebernitz G, Aicher T, Stanton J, Gao J, Shetty S, Knorr D, et al.
J Med Chem
. 2000 Jun;
43(11):2248-57.
PMID: 10841803
The optimization of a series of anilide derivatives of (R)-3,3, 3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase (PDHK) is described that started from N-phenyl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 1 (IC(50) = 35 +/-...
2.
Aicher T, Anderson R, Gao J, Shetty S, Coppola G, Stanton J, et al.
J Med Chem
. 2000 Jan;
43(2):236-49.
PMID: 10649979
N'-methyl-N-(4-tert-butyl-1,2,5,6-tetrahydropyridine)thiourea, SDZ048-619 (1), is a modest inhibitor (IC(50) = 180 microM) of pyruvate dehydrogenase kinase (PDHK). In an optimization of the N-methylcarbothioamide moiety of 1, it was discovered that amides...
3.
Aicher T, Anderson R, Bebernitz G, Coppola G, Jewell C, Knorr D, et al.
J Med Chem
. 1999 Jul;
42(15):2741-6.
PMID: 10425084
No abstract available.
4.
Maniara W, Cipriano A, POWELL M
J Chromatogr B Biomed Sci Appl
. 1998 Apr;
706(2):287-94.
PMID: 9551815
Two simple and sensitive reversed-phase high-performance liquid chromatography (HPLC) methods were developed and validated for the quantitative determination of a novel hypertension drug CGS 25462 and its major metabolites CGS...
5.
Sun J, Walter B, Sandefer E, Page R, Digenis G, Ryo U, et al.
J Clin Pharmacol
. 1996 Mar;
36(3):230-7.
PMID: 8690816
The gastrointestinal absorption of a hypolipidemic agent (CGP 43371) was investigated using an external scintigraphy technique in six healthy men. After an overnight fast, subjects received a single 800-mg oral...
6.
Stelling M, Maniara W, POWELL M
Biomed Chromatogr
. 1994 Nov;
8(6):288-90.
PMID: 7888731
A sensitive and specific analytical method has been developed for the determination of a new anxiolytic (CGS 19480A) in human plasma using high performance liquid chromatography (HPLC). The drug and...
7.
Maniara W, POWELL M
J Chromatogr B Biomed Appl
. 1994 Oct;
660(1):135-42.
PMID: 7858706
A simple, rapid and sensitive normal-phase high-performance liquid chromatographic (HPLC) method was developed and validated for the determination of a novel hypolipidemic agent in human feces, plasma and urine. This...
8.
Stelling M, Maniara W, POWELL M
Biomed Chromatogr
. 1994 Sep;
8(5):247-50.
PMID: 7841770
A quantitative analytical method for the determination of a new thromboxane synthetase inhibitor (CGS 22652) in human plasma has been developed using high performance liquid chromatography (HPLC). The drug and...
9.
Witz G, Kirley T, Maniara W, Mylavarapu V, Goldstein B
Adv Exp Med Biol
. 1991 Jan;
283:613-8.
PMID: 2069029
No abstract available.
10.
Kirley T, Goldstein B, Maniara W, Witz G
Toxicol Appl Pharmacol
. 1989 Sep;
100(2):360-7.
PMID: 2781563
Aldehyde dehydrogenase (ALDH) from yeast, in the presence of NAD+, oxidizes trans, trans-muconaldehyde (MUC) in a biphasic manner with apparent Km values of 0.48 and 3.2 microM and corresponding Vmax...