W Lloyd Ung
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Explore the profile of W Lloyd Ung including associated specialties, affiliations and a list of published articles.
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10
Citations
733
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Recent Articles
1.
A High-Throughput Screening System Based on Droplet Microfluidics for Glucose Oxidase Gene Libraries
Prodanovic R, Ung W, Ilic durdic K, Fischer R, Weitz D, Ostafe R
Molecules
. 2020 May;
25(10).
PMID: 32455903
Glucose oxidase (GOx) is an important industrial enzyme that can be optimized for specific applications by mutagenesis and activity-based screening. To increase the efficiency of this approach, we have developed...
2.
Pel J, Leung A, Choi W, Despotovic M, Ung W, Shibahara G, et al.
PLoS One
. 2018 Dec;
13(12):e0208283.
PMID: 30517195
Targeted Next Generation Sequencing (NGS) is being adopted increasingly broadly in many research, commercial and clinical settings. Currently used target capture methods, however, typically require complex and lengthy (sometimes multi-day)...
3.
Pel J, Choi W, Leung A, Shibahara G, Gelinas L, Despotovic M, et al.
PLoS One
. 2018 Oct;
13(10):e0204265.
PMID: 30278055
A challenge in the clinical adoption of cell-free DNA (cfDNA) liquid biopsies for cancer care is their high cost compared to potential reimbursement. The most common approach used in liquid...
4.
Rotem A, Serohijos A, Chang C, Wolfe J, Fischer A, Mehoke T, et al.
Mol Biol Evol
. 2018 Jun;
35(10):2390-2400.
PMID: 29955873
Viral evolutionary pathways are determined by the fitness landscape, which maps viral genotype to fitness. However, a quantitative description of the landscape and the evolutionary forces on it remain elusive....
5.
Ding R, Ung W, Heyman J, Weitz D
Biomicrofluidics
. 2017 Mar;
11(1):014114.
PMID: 28344725
Active manipulation of droplets is crucial in droplet microfluidics. However, droplet polydispersity decreases the accuracy of active manipulation. We develop a microfluidic "droplet filter" that accurately separates droplets by size....
6.
Ostafe R, Prodanovic R, Ung W, Weitz D, Fischer R
Biomicrofluidics
. 2014 Nov;
8(4):041102.
PMID: 25379082
A new ultra-high-throughput screening assay for the detection of cellulase activity was developed based on microfluidic sorting. Cellulase activity is detected using a series of coupled enzymes leading to the...
7.
Duncanson W, Arriaga L, Ung W, Kopechek J, Porter T, Weitz D
Langmuir
. 2014 Oct;
30(46):13765-70.
PMID: 25340527
The ability of low boiling point liquid perfluorocarbons (PFCs) to undergo a phase change from a liquid to a gas upon ultrasound irradiation makes PFC-based emulsions promising vehicles for triggered...
8.
Jarosz D, Brown J, Walker G, Datta M, Ung W, Lancaster A, et al.
Cell
. 2014 Aug;
158(5):1083-1093.
PMID: 25171409
In experimental science, organisms are usually studied in isolation, but in the wild, they compete and cooperate in complex communities. We report a system for cross-kingdom communication by which bacteria...
9.
Mazutis L, Gilbert J, Ung W, Weitz D, Griffiths A, Heyman J
Nat Protoc
. 2013 Apr;
8(5):870-91.
PMID: 23558786
We present a droplet-based microfluidics protocol for high-throughput analysis and sorting of single cells. Compartmentalization of single cells in droplets enables the analysis of proteins released from or secreted by...
10.
Rowat A, Jaalouk D, Zwerger M, Ung W, Eydelnant I, Olins D, et al.
J Biol Chem
. 2013 Jan;
288(12):8610-8618.
PMID: 23355469
Neutrophils are characterized by their distinct nuclear shape, which is thought to facilitate the transit of these cells through pore spaces less than one-fifth of their diameter. We used human...