W L Shoop
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Explore the profile of W L Shoop including associated specialties, affiliations and a list of published articles.
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53
Citations
393
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Recent Articles
1.
Shoop W, Xiong Y, Wiltsie J, Woods A, Guo J, Pivnichny J, et al.
Proc Natl Acad Sci U S A
. 2005 May;
102(22):7958-63.
PMID: 15911756
The primary virulence factor of Bacillus anthracis is a secreted zinc-dependent metalloprotease toxin known as lethal factor (LF) that is lethal to the host through disruption of signaling pathways, cell...
2.
Ondeyka J, Dombrowski A, Polishook J, Felcetto T, Shoop W, Guan Z, et al.
J Ind Microbiol Biotechnol
. 2003 Apr;
30(4):220-4.
PMID: 12687496
Mellamide, a novel indole amide, was isolated from a fermentation of Aspergillus melleus using silica gel and high-performance liquid chromatographic methods. This allowed its separation from three known antiparasitic compounds...
3.
Shoop W, Michael B, Eary C, Haines H
J Parasitol
. 2002 Jul;
88(3):536-9.
PMID: 12099422
Vertical transmission of larvae is a major pathway in the life cycle of several species of Strongyloides, but evidence for it occurring in humans or dogs with Strongyloides stercoralis is...
4.
Felcetto T, Ondeyka J, Colletti S, Meinke P, Shoop W
J Parasitol
. 2002 Jun;
88(2):223-6.
PMID: 12053989
A medicinal chemistry program on the nodulisporic acid chemical class, guided by an artificial membrane flea-feeding assay, has recently identified permissive and nonpermissive regions of the pharmacophore for exploitation against...
5.
Berger R, Shoop W, Pivnichny J, Warmke L, Owens K, DeMontigny P, et al.
Org Lett
. 2001 Nov;
3(23):3715-8.
PMID: 11700120
[reaction--see text] The semisynthetic conversion of nodulisporic acid A (1) into a set of three heterocyclic side chain derivatives provided compounds, highlighted by 6, with an improved spectrum of ectoparasiticidal...
6.
Shoop W, Gregory L, Michael B, Pivnichny J, Meinke P, Fisher M, et al.
J Parasitol
. 2001 Nov;
87(5):1150-4.
PMID: 11695382
Nodulisporic acid A (NSA) has been shown previously to be safe in dogs and to deliver >90% flea control for 4 days following a single oral administration. Three newly prepared...
7.
Gregory L, Meinke P, Shoop W
J Med Entomol
. 2001 Jul;
38(4):576-80.
PMID: 11476339
Ivermectin has potent systemic activity against numerous species of nematodes and arthropods, but there are some important species in these two groups, such as the cat flea, Ctenocephalides felis (Bouché),...
8.
Shoop W, Gregory L, Michael B, Haines H, Ondeyka J, Meinke P, et al.
J Parasitol
. 2001 Apr;
87(2):419-23.
PMID: 11318575
Nodulisporic acid A (NSA) is a novel natural product from a new structural class that was shown previously to have insecticidal activity against blowfly larvae. To determine if there was...
9.
Meinke P, Ayer M, Colletti S, Li C, Lim J, Ok D, et al.
Bioorg Med Chem Lett
. 2000 Oct;
10(20):2371-4.
PMID: 11055358
Medicinal chemistry efforts were initiated to identify the key constituents of the nodulisporic acid A (1) pharmacophore that are integral to its potent insecticidal activity. New semisynthetic derivatives delineated 1...
10.
Gregory L, Shoop W
J Med Entomol
. 2000 Aug;
37(4):571-4.
PMID: 10916298
Larvae of the cat flea, Ctenocephalides felis (Bouché), are the target of numerous growth regulators. This study explores the development of an assay that tests the susceptibility of cat flea...