W L McKeehan
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Explore the profile of W L McKeehan including associated specialties, affiliations and a list of published articles.
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136
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2978
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Recent Articles
1.
Liu J, You P, Chen G, Fu X, Zeng X, Wang C, et al.
Oncogene
. 2015 Jun;
35(14):1750-9.
PMID: 26096936
Metastasis of tumors requires angiogenesis, which is comprised of multiple biological processes that are regulated by angiogenic factors. The fibroblast growth factor (FGF) is a potent angiogenic factor and aberrant...
2.
Emmenegger B, Hwang E, Moore C, Markant S, Brun S, Dutton J, et al.
Oncogene
. 2012 Oct;
32(35):4181-8.
PMID: 23045271
Cerebellar granule neurons are the most abundant neurons in the brain, and a critical element of the circuitry that controls motor coordination and learning. In addition, granule neuron precursors (GNPs)...
3.
Ye S, Luo Y, Lu W, Jones R, Linhardt R, Capila I, et al.
Biochemistry
. 2001 Nov;
40(48):14429-39.
PMID: 11724555
Stromal cell-derived FGF-7 binds and activates only the resident FGFR2IIIb in epithelial cells while FGF-1 and FGF-2 exhibit a broader interaction with multiple isoforms of FGFR. Here we report the...
4.
Zhang Y, Wang H, Toratani S, Sato J, Kan M, McKeehan W, et al.
Proc Natl Acad Sci U S A
. 2001 Sep;
98(20):11336-40.
PMID: 11562460
We have reported that normal human salivary gland-derived epithelial cells exclusively express keratinocyte growth factor receptor (KGFR). In the process of malignant transformation of human salivary gland tumors, KGFR gene...
5.
Jones R, Carstens R, Luo Y, McKeehan W
Nucleic Acids Res
. 2001 Aug;
29(17):3557-65.
PMID: 11522825
The cell type-specific, mutually-exclusive alternative splicing of the fibroblast growth factor receptor 2 (FGFR2) pre-mRNA is tightly regulated. A sequence termed ISAR (intronic splicing activator and repressor) has been implicated...
6.
Wu X, Kan M, Wang F, Jin C, Yu C, McKeehan W
Cancer Res
. 2001 Jun;
61(13):5295-302.
PMID: 11431373
The abnormal appearance and age-dependent loss of resident fibroblast growth factor receptor-2 (FGFR2) and gain of activity of FGFR1 in epithelial cells is a hallmark of the slow progression to...
7.
Liu Y, Ahmad H, Luo Y, Gardiner D, Gunasekera R, McKeehan W, et al.
J Agric Food Chem
. 2001 Jun;
49(6):3051-7.
PMID: 11410008
This study was undertaken to characterize the pectin from four citrus species and to determine their in vitro inhibitory activities on the binding of fibroblast growth factor (FGF) to the...
8.
Uematsu F, Jang J, Kan M, Wang F, Luo Y, McKeehan W
Biochem Biophys Res Commun
. 2001 May;
283(4):791-7.
PMID: 11350054
Models of the oligomeric FGF signaling complex, including those derived from crystal structures, vary in stoichiometry and arrangement of the three subunits comprised of heparin/heparan sulfate chains, FGFR tyrosine kinase...
9.
Jones R, Wang F, Luo Y, Yu C, Jin C, Suzuki T, et al.
J Biol Chem
. 2000 Oct;
276(6):4158-67.
PMID: 11042206
Exons IIIb and IIIc of the FGFR2 gene are alternatively spliced in a mutually exclusive manner in different cell types. A switch from expression of FGFR2IIIb to FGFR2IIIc accompanies the...
10.
Jang J, Shin K, Park Y, Lee R, McKeehan W, Park J
Cancer Res
. 2000 Aug;
60(15):4049-52.
PMID: 10945607
A nested reverse transcription-PCR analysis of FGFR3 from human colorectal carcinomas revealed novel mutant transcripts caused by aberrant splicing and activation of cryptic splice sequences. Two aberrantly spliced transcripts were...