W Jason Cummings
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Explore the profile of W Jason Cummings including associated specialties, affiliations and a list of published articles.
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12
Citations
220
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Recent Articles
1.
Dudler T, Yaseen S, Cummings W
Front Immunol
. 2023 Nov;
14:1297352.
PMID: 38022610
Introduction: Overactivation of the lectin pathway of complement plays a pathogenic role in a broad range of immune-mediated and inflammatory disorders; mannan-binding lectin-associated serine protease-2 (MASP-2) is the key effector...
2.
Yaseen S, Demopulos G, Dudler T, Yabuki M, Wood C, Cummings W, et al.
FASEB J
. 2017 Feb;
31(5):2210-2219.
PMID: 28188176
All 3 activation pathways of complement-the classic pathway (CP), the alternative pathway, and the lectin pathway (LP)- converge into a common central event: the cleavage and activation of the abundant...
3.
Orsini F, Chrysanthou E, Dudler T, Cummings W, Takahashi M, Fujita T, et al.
J Neuroinflammation
. 2016 Sep;
13(1):213.
PMID: 27577570
Background: Complement activation via the lectin activation pathway (LP) has been identified as the key mechanism behind post-ischemic tissue inflammation causing ischemia-reperfusion injury (IRI) which can significantly impact the clinical...
4.
Yabuki M, Cummings W, Leppard J, Immormino R, Wood C, Allison D, et al.
PLoS One
. 2012 May;
7(4):e36032.
PMID: 22558313
Monoclonal antibodies (mAbs) can be potent and highly specific therapeutics, diagnostics and research reagents. Nonetheless, mAb discovery using current in vivo or in vitro approaches can be costly and time-consuming,...
5.
Ordinario E, Yabuki M, Handa P, Cummings W, Maizels N
BMC Mol Biol
. 2009 Oct;
10:98.
PMID: 19863810
Background: Gene conversion depends upon the same factors that carry out more general process of homologous recombination, including homologous gene targeting and recombinational repair. Among these are the RAD51 paralogs,...
6.
Cummings W, Bednarski D, Maizels N
PLoS One
. 2008 Dec;
3(12):e4075.
PMID: 19115012
Homologous recombination is essential for maintaining genomic integrity. A common repair mechanism, it uses a homologous or homeologous donor as a template for repair of a damaged target gene. Such...
7.
Yabuki M, Ordinario E, Cummings W, Fujii M, Maizels N
J Immunol
. 2008 Dec;
182(1):408-15.
PMID: 19109172
Rearranged Ig genes undergo diversification in sequence and structure initiated by the DNA deaminase, activation-induced deaminase. Ig genes must be transcribed for diversification to occur, but whether there are additional...
8.
Cummings W, Yabuki M, Ordinario E, Bednarski D, Quay S, Maizels N
PLoS Biol
. 2007 Sep;
5(10):e246.
PMID: 17880262
Homology-directed repair is a powerful mechanism for maintaining and altering genomic structure. We asked how chromatin structure contributes to the use of homologous sequences as donors for repair using the...
9.
Larson E, Cummings W, Bednarski D, Maizels N
Mol Cell
. 2005 Nov;
20(3):367-75.
PMID: 16285919
MRE11/RAD50/NBS1 (MRN) is a ubiquitous complex that participates in the response to DNA damage and in immunoglobulin (Ig) gene diversification. Ig gene diversification is initiated by deamination of cytosine to...
10.
Baxter E, Cummings W, Fournier R
Nucleic Acids Res
. 2005 Jun;
33(10):3313-22.
PMID: 15942032
The human serine protease inhibitor (serpin) gene cluster at 14q32.1 is a useful model system to study cell-type-specific gene expression and chromatin structure. Activation of the serpin locus can be...