W J Strittmatter
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Explore the profile of W J Strittmatter including associated specialties, affiliations and a list of published articles.
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89
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8970
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Recent Articles
1.
Cooper A, Sheu K, Burke J, Onodera O, Strittmatter W, Roses A, et al.
Age (Omaha)
. 2013 Apr;
21(1):25-30.
PMID: 23604331
At least seven adult-onset neurodegenerative diseases, including Huntington's disease (HD), are caused by genes containing expanded CAG triplets within their coding regions. The expanded CAG repeats give rise to extended...
2.
Weinberg J, Volkheimer A, Mihovilovic M, Jiang N, Chen Y, Bond K, et al.
Leukemia
. 2008 Sep;
22(12):2184-92.
PMID: 18784741
Survival of chronic lymphocytic leukemia (CLL) cells requires sustained activation of the antiapoptotic PI-3-K/Akt pathway, and many therapies for CLL cause leukemia cell death by triggering apoptosis. Blood lipoprotein particles...
3.
Colton C, Xu Q, Burke J, Bae S, Wakefield J, Nair A, et al.
J Neurosci
. 2004 Aug;
24(32):7118-27.
PMID: 15306645
Our data suggest a novel mechanism whereby pathological-length polyglutamine (polyQ) proteins promote the spermine synthetic pathway, increasing polyQ-aggregation and cell death. As detected in a cell-free turbidity assay, spermine promotes...
4.
Lai T, Tucker T, Burke J, Strittmatter W, Greenberg C
J Neurochem
. 2004 Mar;
88(5):1253-60.
PMID: 15009681
The expansion of a polyglutamine (polyQ) domain in neuronal proteins is the molecular genetic cause of at least eight neurodegenerative diseases. Proteins with a polyQ domain that is greater than...
5.
Ren H, Nagai Y, Tucker T, Strittmatter W, Burke J
Biochem Biophys Res Commun
. 2001 Oct;
288(3):703-10.
PMID: 11676500
Proteins with expanded polyglutamine domains cause eight inherited neurodegenerative diseases including Huntington's disease. In a previous paper, we identified peptides that inhibit polyglutamine protein aggregation and cell death and now...
6.
Strittmatter W
Biochem Soc Symp
. 2001 Jul;
(67):101-9.
PMID: 11447826
The three common apolipoprotein E (ApoE) alleles differentially contribute to the risk of Alzheimer's disease (AD). While the APOE genotype alters susceptibility to disease expression, individuals with APOE epsilon 4...
7.
Fullerton S, SHIRMAN G, Strittmatter W, Matthew W
Exp Neurol
. 2001 Apr;
169(1):13-22.
PMID: 11312553
Apolipoprotein E (apoE) is well characterized as a plasma lipoprotein involved in lipid and cholesterol metabolism. Recent studies implicating apoE in Alzheimer's disease and successful recovery from neurological injury have...
8.
Strittmatter W
Ann N Y Acad Sci
. 2001 Feb;
924:91-2.
PMID: 11193808
The specific molecular pathway by which apolipoprotein E modifies the expression of Alzheimer's disease remains elusive. Isoform-specific interactions of apolipoprotein E with other molecules determine the outcome from other neurologic...
9.
Bedlack R, Strittmatter W, Morgenlander J
Arch Neurol
. 2000 Nov;
57(11):1561-5.
PMID: 11074787
Molecular mechanisms that alter the incidence and rate of neuromuscular disease progression are, in many cases, only partially understood. Several recent studies have asked whether apolipoprotein E (apoE for the...
10.
Chew S, Newman M, White W, Conlon P, Saunders A, Strittmatter W, et al.
Anesthesiology
. 2000 Jul;
93(2):325-31.
PMID: 10910477
Background: Renal dysfunction after cardiac surgery occurs in up to 8% of patients and is associated with major increases in morbidity, mortality, and cost. Genetic polymorphisms have been implicated as...