W H Moolenaar
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Explore the profile of W H Moolenaar including associated specialties, affiliations and a list of published articles.
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117
Citations
4796
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Recent Articles
1.
Taghavi P, Verhoeven E, Jacobs J, Lambooij J, Stortelers C, Tanger E, et al.
Oncogene
. 2008 Sep;
27(54):6806-16.
PMID: 18762810
c-Myc drives uncontrolled cell proliferation in various human cancers. However, in mouse embryo fibroblasts (MEFs), c-Myc also induces apoptosis by activating the p19Arf tumor suppressor pathway. Tbx2, a transcriptional repressor...
2.
Savaskan N, Rocha L, Kotter M, Baer A, Lubec G, van Meeteren L, et al.
Cell Mol Life Sci
. 2006 Dec;
64(2):230-43.
PMID: 17192809
Autotaxin is a secreted cell motility-stimulating exo-phosphodiesterase with lysophospholipase D activity that generates bioactive lysophosphatidic acid. Lysophosphatidic acid has been implicated in various neural cell functions such as neurite remodeling,...
3.
van Leeuwen F, Giepmans B, van Meeteren L, Moolenaar W
Biochem Soc Trans
. 2003 Dec;
31(Pt 6):1209-12.
PMID: 14641027
LPA (lysophosphatidic acid), the simplest of al glycerophospholipids, is a potent inducer of cell proliferation, migration and survival. It does so by activating its cognate G-protein-coupled receptors, four of which...
4.
Giepmans B, Verlaan I, Moolenaar W
Cell Commun Adhes
. 2002 Jun;
8(4-6):219-23.
PMID: 12064592
Gap junctions are composed of connexins that form transmembrane channels between adjacent cells. The C-terminal tail of connexin-43 (Cx43), the most widely expressed connexin member, has been implicated in the...
5.
Kranenburg O, Verlaan I, Moolenaar W
Curr Biol
. 2001 Dec;
11(23):1880-4.
PMID: 11728312
Cholesterol-rich and caveolin-containing microdomains of the plasma membrane, termed "caveolae," have been implicated in signal transduction. However, the role of caveolae in regulating the Ras-MAP kinase cascade is incompletely understood....
6.
Giepmans B, Verlaan I, Hengeveld T, Janssen H, Calafat J, Falk M, et al.
Curr Biol
. 2001 Sep;
11(17):1364-8.
PMID: 11553331
Gap junctions are specialized cell-cell junctions that mediate intercellular communication. They are composed of connexin proteins, which form transmembrane channels for small molecules [1, 2]. The C-terminal tail of connexin-43...
7.
Kranenburg O, Moolenaar W
Oncogene
. 2001 Apr;
20(13):1540-6.
PMID: 11313900
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are extracellular lipid mediators that signal through distinct members of the Edg/LP subfamily of G protein-coupled receptors (GPCRs). LPA and S1P receptors are expressed...
8.
ANDREEV J, Galisteo M, Kranenburg O, Logan S, Chiu E, Okigaki M, et al.
J Biol Chem
. 2001 Mar;
276(23):20130-5.
PMID: 11274221
The epidermal growth factor receptor (EGFR) and the non-receptor protein tyrosine kinases Src and Pyk2 have been implicated in linking a variety of G-protein-coupled receptors (GPCR) to the mitogen-activated protein...
9.
Postma F, Jalink K, Hengeveld T, Offermanns S, Moolenaar W
Curr Biol
. 2001 Mar;
11(2):121-4.
PMID: 11231129
Loss of membrane potential (membrane depolarization) is one of the earliest and most striking responses of quiescent cells to stimulation with serum or G protein-coupled receptor (GPCR) agonists such as...
10.
Zondag G, Reynolds A, Moolenaar W
J Biol Chem
. 2001 Feb;
275(15):11264-9.
PMID: 10753936
RPTPmu is a prototypic receptor-like protein-tyrosine phosphatase (RPTP) that mediates homotypic cell-cell interactions. Intracellularly, RPTPmu consists of a relatively large juxtamembrane region and two phosphatase domains, but little is still...