W H Davin Townley-Tilson
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Explore the profile of W H Davin Townley-Tilson including associated specialties, affiliations and a list of published articles.
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13
Citations
474
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Recent Articles
1.
Ssengonzi R, Wang Y, Zhou J, Kayashima Y, Townley-Tilson W, Rao B, et al.
Life (Basel)
. 2025 Jan;
14(12.
PMID: 39768370
In preeclampsia (PE), impaired trophoblast proliferation and differentiation are thought to cause abnormal placentation and subsequent clinical manifestations of the disease, i.e., hypertension, proteinuria, and end-organ damage. Insulin-like growth factor-1...
2.
Wang Y, Ssengonzi R, Townley-Tilson W, Kayashima Y, Maeda-Smithies N, Li F
Int J Mol Sci
. 2024 Aug;
25(16).
PMID: 39201703
Preeclampsia is a complex pregnancy-related hypertensive disorder which poses significant risks for both maternal and fetal health. Preeclampsia affects 5-8% of pregnancies in the United States, causing a significant public...
3.
Zhou J, Franceschini N, Townley-Tilson W, Maeda-Smithies N
Nutrients
. 2024 Jun;
16(12).
PMID: 38931271
Diabetic nephropathy (DN), defined as continuously elevated urinary albumin and a diminished estimated glomerular filtration rate, is a serious complication of both type 1 diabetes and type 2 diabetes and...
4.
Kayashima Y, Townley-Tilson W, Vora N, Boggess K, Homeister J, Maeda-Smithies N, et al.
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36768469
Obesity is a risk factor for preeclampsia. We investigated how obesity influences preeclampsia in mice lacking ankyrin-repeat-and-SOCS-box-containing-protein 4 (ASB4), which promotes trophoblast differentiation via degrading the inhibitor of DNA-binding protein...
5.
LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell Proliferation
Mao H, Lockyer P, Townley-Tilson W, Xie L, Pi X
Arterioscler Thromb Vasc Biol
. 2015 Dec;
36(2):350-60.
PMID: 26634655
Objective: We recently demonstrated that low-density lipoprotein receptor-related protein 1 (LRP1) is required for cardiovascular development in zebrafish. However, what role LRP1 plays in angiogenesis remains to be determined. To...
6.
Townley-Tilson W, Pi X, Xie L
Oxid Med Cell Longev
. 2015 Oct;
2015:676893.
PMID: 26491535
Ischemic heart disease is the leading cause of death worldwide. Oxygen-sensing proteins are critical components of the physiological response to hypoxia and reperfusion injury, but the role of oxygen and...
7.
Xie L, Pi X, Townley-Tilson W, Li N, Wehrens X, Entman M, et al.
J Clin Invest
. 2015 Jun;
125(7):2759-71.
PMID: 26075818
Ischemic heart disease is the leading cause of heart failure. Both clinical trials and experimental animal studies demonstrate that chronic hypoxia can induce contractile dysfunction even before substantial ventricular damage,...
8.
Townley-Tilson W, Wu Y, Ferguson 3rd J, Patterson C
PLoS One
. 2014 Mar;
9(2):e89451.
PMID: 24586788
Vascularization of the placenta is a critical developmental process that ensures fetal viability. Although the vascular health of the placenta affects both maternal and fetal well being, relatively little is...
9.
Townley-Tilson W, Callis T, Wang D
Int J Biochem Cell Biol
. 2010 Jul;
42(8):1252-5.
PMID: 20619221
microRNAs (miRNAs) are a class of highly conserved small non-coding RNAs that negatively regulate gene expression post-transcriptionally. miRNAs are known to mediate myriad cell processes, including proliferation, differentiation, and apoptosis....
10.
Willis M, Townley-Tilson W, Kang E, Homeister J, Patterson C
Circ Res
. 2010 Feb;
106(3):463-78.
PMID: 20167943
The ubiquitin proteasome system (UPS) plays a crucial role in biological processes integral to the development of the cardiovascular system and cardiovascular diseases. The UPS prototypically recognizes specific protein substrates...