W F Drew Bennett
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Explore the profile of W F Drew Bennett including associated specialties, affiliations and a list of published articles.
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40
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Recent Articles
11.
Bennett W, He S, Bilodeau C, Jones D, Sun D, Kim H, et al.
J Chem Inf Model
. 2020 Aug;
60(11):5375-5381.
PMID: 32794768
Accurately predicting small molecule partitioning and hydrophobicity is critical in the drug discovery process. There are many heterogeneous chemical environments within a cell and entire human body. For example, drugs...
12.
Ingolfsson H, Bhatia H, Zeppelin T, Bennett W, Carpenter K, Hsu P, et al.
J Phys Chem B
. 2020 Aug;
124(36):7819-7829.
PMID: 32790367
Plasma membranes (PMs) contain hundreds of different lipid species that contribute differently to overall bilayer properties. By modulation of these properties, membrane protein function can be affected. Furthermore, inhomogeneous lipid...
13.
Sun D, Peyear T, Bennett W, Andersen O, Lightstone F, Ingolfsson H
Biophys J
. 2019 Nov;
117(10):1831-1844.
PMID: 31676135
Membrane protein functions can be altered by subtle changes in the host lipid bilayer physical properties. Gramicidin channels have emerged as a powerful system for elucidating the underlying mechanisms of...
14.
Bennett W, Shea J, Tieleman D
Biophys J
. 2018 Jun;
114(11):2595-2605.
PMID: 29874610
Cholesterol is a key component of eukaryotic membranes, but its role in cellular biology in general and in lipid rafts in particular remains controversial. Model membranes are used extensively to...
15.
16.
Bennett W, Hong C, Wang Y, Tieleman D
J Chem Theory Comput
. 2016 Aug;
12(9):4524-33.
PMID: 27529120
Due to antimicrobial resistance, the development of new drugs to combat bacterial and fungal infections is an important area of research. Nature uses short, charged, and amphipathic peptides for antimicrobial...
17.
Zhang L, Bennett W, Zheng T, Ouyang P, Ouyang X, Qiu X, et al.
J Phys Chem B
. 2016 Mar;
120(12):3148-56.
PMID: 26937690
The cell membrane is a major barrier for drug transport. Given that many cancer drugs must passively cross the cell membrane, understanding drug-membrane interactions is crucial. We used fluorescence-activated cell...
18.
Bereau T, Bennett W, Pfaendtner J, Deserno M, Karttunen M
J Chem Phys
. 2016 Jan;
143(24):243127.
PMID: 26723612
The anchor of most integral membrane proteins consists of one or several helices spanning the lipid bilayer. The WALP peptide, GWW(LA)n (L)WWA, is a common model helix to study the...
19.
Bennett W, Tieleman D
J Chem Theory Comput
. 2015 Nov;
7(9):2981-8.
PMID: 26605486
Defects in lipid bilayers are important in a range of biological processes, including interactions between antimicrobial peptides and membranes, transport of polar molecules (including drugs) across membranes, and lipid flip-flop...
20.
Neale C, Bennett W, Tieleman D, Pomes R
J Chem Theory Comput
. 2015 Nov;
7(12):4175-88.
PMID: 26598360
In recent years, atomistic molecular simulations have become a method of choice for studying the interaction of small molecules, peptides, and proteins with biological membranes. Here, we critically examine the...