W E Walden
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Explore the profile of W E Walden including associated specialties, affiliations and a list of published articles.
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21
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381
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Recent Articles
1.
Narahari J, Ma R, Wang M, Walden W
J Biol Chem
. 2000 Apr;
275(21):16227-34.
PMID: 10748225
Iron regulatory proteins (IRP) are sequence-specific RNA-binding proteins that mediate iron-responsive gene regulation in animals. IRP1 is also the cytosolic isoform of aconitase (c-aconitase). This latter activity could complement a...
2.
Brown N, Anderson S, Steffen D, Carpenter T, Kennedy M, Walden W, et al.
Proc Natl Acad Sci U S A
. 1998 Dec;
95(26):15235-40.
PMID: 9860952
Animals regulate iron metabolism largely through the action of the iron regulatory proteins (IRPs). IRPs modulate mRNA utilization by binding to iron-responsive elements (IRE) in the 5' or 3' untranslated...
3.
Ke Y, Wu J, Leibold E, Walden W, Theil E
J Biol Chem
. 1998 Sep;
273(37):23637-40.
PMID: 9726965
A family of noncoding mRNA sequences, iron-responsive elements (IREs), coordinately regulate several mRNAs through binding a family of mRNA-specific proteins, iron regulatory proteins (IRPs). IREs are hairpins with a constant...
4.
Swenson G, Walden W
Nucleic Acids Res
. 1994 Jul;
22(13):2627-33.
PMID: 7518918
The iron responsive element binding protein (IRE-BP) regulates iron storage and uptake in response to iron. This control results from the interaction of the IRE-BP with the iron responsive element...
5.
Dix D, Lin P, McKenzie A, Walden W, Theil E
J Mol Biol
. 1993 May;
231(2):230-40.
PMID: 7685392
Ferritin and transferrin receptors are co-ordinately regulated by the same RNA-protein interaction: the conserved iron regulatory element (IRE) in mRNA and the IRE-binding protein (IRE-BP/IRP/FRP/P-90). The 28 nucleotide IRE in...
6.
Patino M, Walden W
J Biol Chem
. 1992 Sep;
267(26):19011-6.
PMID: 1527028
Ferritin synthesis is controlled at the translational level in response to cellular iron status. A component of this regulatory system is the ferritin repressor protein (FRP) which binds to the...
7.
Lin J, Patino M, Gaffield L, Walden W, Smith A, Thach R
Proc Natl Acad Sci U S A
. 1991 Jul;
88(14):6068-71.
PMID: 2068086
Incubation of a 90-kDa ferritin repressor protein (FRP) with small amounts of radiolabeled hemin resulted in the formation of a strong interaction between the two that was stable to SDS/PAGE....
8.
Harrell C, McKenzie A, Patino M, Walden W, Theil E
Proc Natl Acad Sci U S A
. 1991 May;
88(10):4166-70.
PMID: 1903535
The ferritin iron regulatory element (IRE), a conserved sequence of 28 nucleotides in a hairpin loop, is a conserved mRNA-specific translational regulatory element; flanking the IRE are regions of varying...
9.
Swenson G, Patino M, Beck M, Gaffield L, Walden W
Biol Met
. 1991 Jan;
4(1):48-55.
PMID: 1854587
The iron-responsive regulation of ferritin mRNA translation is mediated by the specific interaction of the ferritin repressor protein (FRP) with the iron-responsive element (IRE), a highly conserved 28-nucleotide sequence located...
10.
Lin J, Gaffield L, Patino M, Walden W, Thach R
Biochim Biophys Acta
. 1990 Aug;
1050(1-3):146-50.
PMID: 2169889
We have previously reported that hemin derepresses ferritin mRNA translation in vitro. As noted earlier, pre-incubation of a 90 kDa ferritin repressor protein (FRP) with hemin prevented subsequent repression of...