W E Glaab
Overview
Explore the profile of W E Glaab including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
286
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Recent Articles
1.
LAWS G, Skopek T, Reddy M, Storer R, Glaab W
Mutat Res
. 2001 Dec;
484(1-2):3-18.
PMID: 11733068
The detection of DNA adducts is an important component in assessing the mutagenic potential of exogenous and endogenous compounds. Here, we report an in vitro quantitative long PCR (XL-PCR) assay...
2.
Glaab W, Hill R, Skopek T
Carcinogenesis
. 2001 Sep;
22(10):1709-13.
PMID: 11577013
Genomic instability associated with deficiencies in mismatch repair (MMR) plays a critical role in tumorigenesis. Here we have investigated the contribution of oxidative damage to this instability in MMR-defective cells....
3.
Bleicher K, Pippert T, Glaab W, Skopek T, Sina J, Umbenhauer D
J Biochem Mol Toxicol
. 2001 Jun;
15(3):133-42.
PMID: 11424223
Exposure of rats to peroxisome proliferators induces members of the cytochrome P450 4A (CYP4A) family. In rats, the CYP4A family consists of four related genes, CYP4A1, CYP4A2, CYP4A3, and CYP4A8....
4.
Glaab W, Kort K, Skopek T
Cancer Res
. 2000 Sep;
60(17):4921-5.
PMID: 10987307
Recently, we have shown a hypermutable response to the food-associated heterocyclic amine 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine (PhIP) in human cells defective in mismatch repair (MMR). These findings suggest that exogenous compounds such as...
5.
Skopek T, Glaab W, MONROE J, Kort K, Schaefer W
Mutat Res
. 1999 Dec;
430(1):13-21.
PMID: 10592314
The ability to detect DNA sequence heterogeneity quickly and reliably is becoming increasingly important as more genes involved in disease processes are discovered. We have assessed the ability of a...
6.
Glaab W, Skopek T
Mutat Res
. 1999 Dec;
430(1):1-12.
PMID: 10592313
Recently much attention has been focused on single nucleotide polymorphisms (SNPs) within fundamentally important genes, such as those involved in metabolism, cell growth regulation, and other disease-associated genes. Methodologies for...
7.
Glaab W, Tindall K, Skopek T
Mutat Res
. 1999 Jul;
427(2):67-78.
PMID: 10393261
Recently, we showed that the cytotoxic and mutagenic response in human cells to the model SN2 alkylating agent methyl methanesulfonate (MMS) can be modulated by the mismatch repair (MMR) pathway....
8.
Glaab W, Skopek T
Carcinogenesis
. 1999 Apr;
20(3):391-4.
PMID: 10190551
The cytotoxic and mutagenic effects of 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine (PhIP), a food-associated heterocyclic amine, were measured in three human cancer cell lines possessing different mismatch repair (MMR) defects and in matched cell...
9.
Glaab W, Risinger J, Umar A, Barrett J, Kunkel T, Tindall K
Carcinogenesis
. 1998 Dec;
19(11):1931-7.
PMID: 9855005
Although the resistance to the cytotoxic response of certain DNA damaging agents has been well characterized in cells deficient in mismatch repair, little is known about how such resistance affects...
10.
Glaab W, Risinger J, Umar A, Kunkel T, Barrett J, Tindall K
J Biol Chem
. 1998 Oct;
273(41):26662-9.
PMID: 9756907
The role of specific mismatch repair (MMR) gene products was examined by observing several phenotypic end points in two MMR-deficient human endometrial carcinoma cell lines that were originally isolated from...