W D Sedwick
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Explore the profile of W D Sedwick including associated specialties, affiliations and a list of published articles.
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58
Citations
773
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Recent Articles
1.
Yan T, Schupp J, Hwang H, Wagner M, Berry S, Strickfaden S, et al.
Cancer Res
. 2001 Nov;
61(22):8290-7.
PMID: 11719462
Our previous data demonstrated that cells deficient in MutL homologue-1 (MLH1) expression had a reduced and shorter G(2) arrest after high-dose-rate ionizing radiation (IR), suggesting that the mismatch re pair...
2.
Ma A, Xia L, Littman S, Swinler S, Lader G, Polinkovsky A, et al.
Oncogene
. 2000 May;
19(18):2249-56.
PMID: 10822375
Inactivation of DNA-mismatch repair underlies the genesis of microsatellite unstable (MSI) colon cancers. hPMS2 is one of several genes encoding components of the DNA-mismatch repair complex, and germline hPMS2 mutations...
3.
Chen W, Eshleman J, Aminoshariae M, Ma A, Veloso N, Markowitz S, et al.
J Natl Cancer Inst
. 2000 Mar;
92(6):480-5.
PMID: 10716966
Background: Deficiency of DNA mismatch repair is a common feature of cancers exhibiting instability of microsatellite DNA sequences. Cancers with microsatellite instability are recognizable by their high rate of spontaneous...
4.
Eshleman J, Casey G, Kochera M, Sedwick W, Swinler S, Veigl M, et al.
Oncogene
. 1998 Aug;
17(6):719-25.
PMID: 9715273
Fourteen colorectal cancer cell lines, categorized according to the presence or absence of microsatellite instability, were further analysed for chromosomal stability by karyotyping. NonRER (microsatellite stable) cell lines typically displayed...
5.
Veigl M, Kasturi L, Olechnowicz J, Ma A, Lutterbaugh J, Periyasamy S, et al.
Proc Natl Acad Sci U S A
. 1998 Jul;
95(15):8698-702.
PMID: 9671741
Mutations of DNA mismatch repair genes, including the hMLH1 gene, have been linked to human colon and other cancers in which defective DNA repair is evidenced by the associated instability...
6.
Eshleman J, Donover P, Littman S, Swinler S, Li G, Lutterbaugh J, et al.
Oncogene
. 1998 Apr;
16(9):1125-30.
PMID: 9528854
We describe a novel mutator phenotype in the Vaco411 colon cancer cell line which increases the spontaneous mutation rate 10-100-fold over background. This mutator results primarily in transversion base substitutions...
7.
Eshleman J, Markowitz S, Donover P, Lang E, Lutterbaugh J, Li G, et al.
Oncogene
. 1996 Apr;
12(7):1425-32.
PMID: 8622858
Colon cancer and an increasing number of other cancers have been found to exhibit instability of DNA microsatellite sequences. Such tumors have been designated as replication errors (RER) tumors. However,...
8.
Eshleman J, Lang E, Bowerfind G, Parsons R, Vogelstein B, WILLSON J, et al.
Oncogene
. 1995 Jan;
10(1):33-7.
PMID: 7824277
Hereditary Non-Polyposis Colon Cancer (HNPCC) tumors and some sporadic colon cancers acquire somatic changes in the length of microsatellite sequences. We hypothesized that this 'replication error' (RER) phenotype in these...
9.
Veigl M, Donover S, Anderson R, Akst L, Sedwick C, Sedwick W
Environ Mol Mutagen
. 1995 Jan;
26(1):16-25.
PMID: 7641704
Previous studies of doxorubicin-induced mutations employing F' lacl/lacO as an endogenous gene target have focused on properties of large deletions with 3' endpoints residing in the lacO region of the...
10.
Sedwick W, Anderson R, Baxter J, Donover S, Schneiter S, Veigl M
Mutat Res
. 1995 Jan;
326(1):17-27.
PMID: 7528882
This study explored the possibility that the sequence location of doxorubicin-induced deletion endpoints might relate to DNA structural alterations caused by doxorubicin binding to DNA. The 3'-OH endpoints of doxorubicin-induced...