Volker Bohnert
Overview
Explore the profile of Volker Bohnert including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
669
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0
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Recent Articles
1.
Wang S, Bohnert V, Joseph A, Sudaryo V, Skariah G, Swinderman J, et al.
Proc Natl Acad Sci U S A
. 2023 Dec;
120(52):e2313693120.
PMID: 38117852
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) expression correlates with poor prognosis in many cancers, and we previously discovered that ENPP1 is the dominant hydrolase of extracellular cGAMP: a cancer-cell-produced immunotransmitter that activates...
2.
Wang S, Bohnert V, Joseph A, Sudaryo V, Swinderman J, Yu F, et al.
bioRxiv
. 2023 Jun;
PMID: 37333273
ENPP1 expression correlates with poor prognosis in many cancers, and we previously discovered that ENPP1 is the dominant hydrolase of extracellular cGAMP: a cancer-cell-produced immunotransmitter that activates the anticancer STING...
3.
Carozza J, Cordova A, Brown J, AlSaif Y, Bohnert V, Cao X, et al.
Proc Natl Acad Sci U S A
. 2022 May;
119(21):e2119189119.
PMID: 35588451
The metazoan innate immune second messenger 2′3′-cGAMP is present both inside and outside cells. However, only extracellular cGAMP can be negatively regulated by the extracellular hydrolase ENPP1. Here, we determine...
4.
Cordova A, Ritchie C, Bohnert V, Li L
ACS Cent Sci
. 2021 Jul;
7(6):1073-1088.
PMID: 34235268
Administration of exogenous CDNs to activate the cGAMP-STING pathway is a promising therapeutic strategy to unleash the full potential of cancer immunotherapy. This strategy mirrors the role of endogenous extracellular...
5.
Carozza J, Bohnert V, Nguyen K, Skariah G, Shaw K, Brown J, et al.
Nat Cancer
. 2021 Mar;
1(2):184-196.
PMID: 33768207
2'3'-cyclic GMP-AMP (cGAMP) is an intracellular second messenger that is synthesized in response to cytosolic double-stranded DNA and activates the innate immune STING pathway. Our previous discovery of its extracellular...
6.
Lahey L, Mardjuki R, Wen X, Hess G, Ritchie C, Carozza J, et al.
Mol Cell
. 2020 Nov;
80(4):578-591.e5.
PMID: 33171122
Extracellular 2'3'-cyclic-GMP-AMP (cGAMP) is an immunotransmitter exported by diseased cells and imported into host cells to activate the innate immune STING pathway. We previously identified SLC19A1 as a cGAMP importer,...
7.
Carozza J, Brown J, Bohnert V, Fernandez D, AlSaif Y, Mardjuki R, et al.
Cell Chem Biol
. 2020 Jul;
27(11):1347-1358.e5.
PMID: 32726585
Cancer cells initiate an innate immune response by synthesizing and exporting the small-molecule immunotransmitter cGAMP, which activates the anti-cancer Stimulator of Interferon Genes (STING) pathway in the host. An extracellular...
8.
Bohnert V, Ritchie C, Li L
Immunity
. 2020 Jul;
53(1):8-10.
PMID: 32668231
In this issue, Wu et al. demonstrate the importance of the neglected interferon (IFN)-independent STING signaling axis in mice. They find that although this axis is important for antiviral HSV-1...
9.
Eichhorn L, Kessler F, Bohnert V, Erdfelder F, Reckendorf A, Meyer R, et al.
J Vis Exp
. 2017 Jan;
(118).
PMID: 28060323
In case of apnea, arterial partial pressure of oxygen (pO2) decreases, while partial pressure of carbon dioxide (pCO2) increases. To avoid damage to hypoxia sensitive organs such as the brain,...
10.
Kubler K, Gehrke N, Riemann S, Bohnert V, Zillinger T, Hartmann E, et al.
Cancer Res
. 2010 Jun;
70(13):5293-304.
PMID: 20551064
Most malignant cells are poorly immunogenic and fail to elicit an effective antitumor immune response. In contrast, viral infections of cells are promptly detected and eliminated by the immune system....