Vivian Saridakis
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Explore the profile of Vivian Saridakis including associated specialties, affiliations and a list of published articles.
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21
Citations
706
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Recent Articles
1.
Bojagora A, Saridakis V
Virus Res
. 2020 Jul;
286:198076.
PMID: 32603670
Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme (DUB) that plays critical roles in the regulation of many cellular processes including epigenetics, tumour suppression, oncogenesis, DNA damage response, immunity...
2.
Gagarina V, Bojagora A, Lacdao I, Luthra N, Pfoh R, Mohseni S, et al.
J Mol Biol
. 2019 Dec;
432(4):897-912.
PMID: 31866294
USP7 is a deubiquitinase that regulates many diverse cellular processes, including tumor suppression, epigenetics, and genome stability. Several substrates, including GMPS, UHRF1, and ICP0, were shown to bear a specific...
3.
Wheaton K, Sarkari F, Stanly Johns B, Davarinejad H, Egorova O, Kaustov L, et al.
J Biol Chem
. 2017 Jan;
292(7):2893-2902.
PMID: 28073915
UbE2E1/UbcH6 is an E2 ubiquitin-conjugating enzyme that is regulated by USP7. We identified UbE2E1 as a novel component of Polycomb repressive complex 1 (PRC1), the E3 ligase complex responsible for...
4.
Smirnova E, Kwan J, Siu R, Gao X, Zoidl G, Demeler B, et al.
Cell Commun Signal
. 2016 Aug;
14(1):17.
PMID: 27549312
Background: CASKIN2 is a homolog of CASKIN1, a scaffolding protein that participates in a signaling network with CASK (calcium/calmodulin-dependent serine kinase). Despite a high level of homology between CASKIN2 and...
5.
Chavoshi S, Egorova O, Lacdao I, Farhadi S, Sheng Y, Saridakis V
J Biol Chem
. 2016 Jan;
291(12):6281-91.
PMID: 26786098
Viral interferon regulatory factor 1 (vIRF1), a Kaposi sarcoma herpesvirus protein, destabilizes p53 by inhibiting p53 acetylation and Hdm2 phosphorylation. This leads to increased ubiquitination and degradation of p53 by...
6.
Pfoh R, Pai E, Saridakis V
Acta Crystallogr D Biol Crystallogr
. 2015 Oct;
71(Pt 10):2032-9.
PMID: 26457427
Nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes the biosynthesis of NAD(+) and NaAD(+). The crystal structure of NMNAT from Methanobacterium thermoautotrophicum complexed with NAD(+) and SO4(2-) revealed the active-site residues involved in...
7.
Pfoh R, Lacdao I, Georges A, Capar A, Zheng H, Frappier L, et al.
PLoS Pathog
. 2015 Jun;
11(6):e1004950.
PMID: 26046769
Herpes simplex virus-1 immediate-early protein ICP0 activates viral genes during early stages of infection, affects cellular levels of multiple host proteins and is crucial for effective lytic infection. Being a...
8.
Pfoh R, Lacdao I, Saridakis V
Endocr Relat Cancer
. 2015 Jan;
22(1):T35-54.
PMID: 25605410
Deubiquitinases (DUBs) play important roles and therefore are potential drug targets in various diseases including cancer and neurodegeneration. In this review, we recapitulate structure-function studies of the most studied DUBs...
9.
Jagannathan M, Nguyen T, Gallo D, Luthra N, Brown G, Saridakis V, et al.
Mol Cell Biol
. 2013 Nov;
34(1):132-45.
PMID: 24190967
The minichromosome maintenance (MCM) complex, which plays multiple important roles in DNA replication, is loaded onto chromatin following mitosis, remains on chromatin until the completion of DNA synthesis, and then...
10.
Sarkari F, Wheaton K, La Delfa A, Mohamed M, Shaikh F, Khatun R, et al.
J Biol Chem
. 2013 Apr;
288(23):16975-16985.
PMID: 23603909
Ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme found in all eukaryotes that catalyzes the removal of ubiquitin from specific target proteins. Here, we report that UbE2E1, an E2 ubiquitin...