Vishwanath Jogini
Overview
Explore the profile of Vishwanath Jogini including associated specialties, affiliations and a list of published articles.
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25
Citations
2084
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Recent Articles
1.
Koldso H, Jensen M, Jogini V, Shaw D
Structure
. 2023 Sep;
31(12):1556-1566.e3.
PMID: 37729917
The cation channel TRPA1 is a potentially important drug target, and characterization of TRPA1 functional dynamics might help guide structure-based drug design. Here, we present results from long-timescale molecular dynamics...
2.
Jogini V, Jensen M, Shaw D
J Gen Physiol
. 2022 Dec;
155(2).
PMID: 36524993
Inward-rectifier potassium channels (Kirs) are lipid-gated ion channels that differ from other K+ channels in that they allow K+ ions to flow more easily into, rather than out of, the...
3.
Unterweger A, Jensen M, Giordanetto F, Jogini V, Ruschher A, Seuss M, et al.
J Crohns Colitis
. 2021 Apr;
15(11):1943-1958.
PMID: 33891001
Background And Aims: The potassium channel Kv1.3 is a potentially attractive therapeutic target in T cell-mediated inflammatory diseases, as the activity of antigen-activated T cells is selectively impeded by Kv1.3...
4.
Song X, Jensen M, Jogini V, Stein R, Lee C, Mchaourab H, et al.
Nature
. 2018 Apr;
556(7702):515-519.
PMID: 29670280
The NMDA (N-methyl-D-aspartate) receptor transduces the binding of glutamate and glycine, coupling it to the opening of a calcium-permeable ion channel . Owing to the lack of high-resolution structural studies...
5.
Jensen M, Jogini V, Eastwood M, Shaw D
J Gen Physiol
. 2013 Apr;
141(5):619-32.
PMID: 23589581
The difficulty in characterizing ion conduction through membrane channels at the level of individual permeation events has made it challenging to elucidate the mechanistic principles underpinning this fundamental physiological process....
6.
Li Q, Jogini V, Wanderling S, Cortes D, Perozo E
Biochemistry
. 2012 Sep;
51(41):8132-42.
PMID: 22989304
The voltage-sensing domain (VSD) is the common scaffold responsible for the functional behavior of voltage-gated ion channels, voltage sensitive enzymes, and proton channels. Because of the position of the voltage...
7.
Raghuraman H, Cordero-Morales J, Jogini V, Pan A, Kollewe A, Roux B, et al.
Structure
. 2012 Jul;
20(8):1332-42.
PMID: 22771214
In K+ channels, rearrangements of the pore outer vestibule have been associated with C-type inactivation gating. Paradoxically, the crystal structure of Open/C-type inactivated KcsA suggests these movements to be modest...
8.
Jensen M, Jogini V, Borhani D, Leffler A, Dror R, Shaw D
Science
. 2012 Apr;
336(6078):229-33.
PMID: 22499946
The mechanism of ion channel voltage gating-how channels open and close in response to voltage changes-has been debated since Hodgkin and Huxley's seminal discovery that the crux of nerve conduction...
9.
Cordero-Morales J, Jogini V, Chakrapani S, Perozo E
Biophys J
. 2011 May;
100(10):2387-93.
PMID: 21575572
In the prokaryotic potassium channel KcsA activation gating at the inner bundle gate is followed by C-type inactivation at the selectivity filter. Entry into the C-type inactivated state has been...
10.
Chakrapani S, Cordero-Morales J, Jogini V, Pan A, Cortes D, Roux B, et al.
Nat Struct Mol Biol
. 2010 Dec;
18(1):67-74.
PMID: 21186363
Modal-gating shifts represent an effective regulatory mechanism by which ion channels control the extent and time course of ionic fluxes. Under steady-state conditions, the K(+) channel KcsA shows three distinct...