Virpi Talman
Overview
Explore the profile of Virpi Talman including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
793
Followers
0
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Recent Articles
1.
Suominen A, Suni A, Ruohonen S, Szabo Z, Pohjolainen L, Cai M, et al.
J Am Heart Assoc
. 2025 Feb;
14(4):e037961.
PMID: 39921516
Background: The melanocortin 1 receptor (MC1R) is abundantly expressed in the skin and leukocytes, where it regulates skin pigmentation and inflammatory responses. Recently, MC1R was also found in the heart,...
2.
Pohjolainen L, Ruskoaho H, Talman V
J Mol Cell Cardiol Plus
. 2025 Jan;
2():100020.
PMID: 39802492
Left ventricular hypertrophy, characterized by hypertrophy of individual cardiomyocytes, is an adaptive response to an increased cardiac workload that eventually leads to heart failure. Previous studies using neonatal rat ventricular...
3.
Majid Q, Ghimire B, Merkely B, Randi A, Harding S, Talman V, et al.
Angiogenesis
. 2024 May;
27(3):561-582.
PMID: 38775849
Coronary microvascular disease (CMD) and its progression towards major adverse coronary events pose a significant health challenge. Accurate in vitro investigation of CMD requires a robust cell model that faithfully...
4.
Jumppanen M, Kinnunen S, Zore M, Valimaki M, Talman V, Gennas G, et al.
Sci Rep
. 2024 Apr;
14(1):8938.
PMID: 38637629
Heart failure is a serious medical condition with a poor prognosis. Current treatments can only help manage the symptoms and slow the progression of heart failure. However, there is currently...
5.
Suominen A, Saldo Rubio G, Ruohonen S, Szabo Z, Pohjolainen L, Ghimire B, et al.
EMBO Rep
. 2024 Mar;
25(4):1987-2014.
PMID: 38454158
α-Melanocyte-stimulating hormone (α-MSH) regulates diverse physiological functions by activating melanocortin receptors (MC-R). However, the role of α-MSH and its possible target receptors in the heart remain completely unknown. Here we...
6.
Pohjolainen L, Kinnunen S, Auno S, Kiriazis A, Pohjavaara S, Kari-Koskinen J, et al.
Stem Cell Res Ther
. 2024 Jan;
15(1):5.
PMID: 38167208
Background: The prevalence of heart failure is constantly increasing, and the prognosis of patients remains poor. New treatment strategies to preserve cardiac function and limit cardiac hypertrophy are therefore urgently...
7.
Chaudhari U, Pohjolainen L, Ruskoaho H, Talman V
Front Cardiovasc Med
. 2023 Jun;
10:1148618.
PMID: 37283582
Background: After birth, mammalian cardiomyocytes substantially lose proliferative capacity with a concomitant switch from glycolytic to oxidative mitochondrial energy metabolism. Micro-RNAs (miRNAs) regulate gene expression and thus control various cellular...
8.
Lautala S, Provenzani R, Tarvainen I, Sirna K, Karhu S, Grazhdankin E, et al.
J Med Chem
. 2023 Apr;
66(7):4588-4602.
PMID: 37010933
Protein kinase C (PKC) modulators hold therapeutic potential for various diseases, including cancer, heart failure, and Alzheimer's disease. Targeting the C1 domain of PKC represents a promising strategy; the available...
9.
Huethorst E, Mortensen P, Simitev R, Gao H, Pohjolainen L, Talman V, et al.
J Physiol
. 2021 Nov;
600(3):483-507.
PMID: 34761809
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) in monolayers interact mechanically via cell-cell and cell-substrate adhesion. Spatiotemporal features of contraction were analysed in hiPSC-CM monolayers (1) attached to glass or...
10.
Tarvainen I, Nunn R, Tuominen R, Jantti M, Talman V
J Pharmacol Exp Ther
. 2021 Oct;
380(1):54-62.
PMID: 34697230
Colorectal cancer is the third most commonly occurring cancer in men and the second in women. The global burden of colorectal cancer is projected to increase to over 2 million...