Heikki Ruskoaho
Overview
Explore the profile of Heikki Ruskoaho including associated specialties, affiliations and a list of published articles.
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141
Citations
2606
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Recent Articles
1.
Pohjolainen L, Ruskoaho H, Talman V
J Mol Cell Cardiol Plus
. 2025 Jan;
2():100020.
PMID: 39802492
Left ventricular hypertrophy, characterized by hypertrophy of individual cardiomyocytes, is an adaptive response to an increased cardiac workload that eventually leads to heart failure. Previous studies using neonatal rat ventricular...
2.
Suominen A, Saldo Rubio G, Ruohonen S, Szabo Z, Pohjolainen L, Ghimire B, et al.
EMBO Rep
. 2024 Mar;
25(4):1987-2014.
PMID: 38454158
α-Melanocyte-stimulating hormone (α-MSH) regulates diverse physiological functions by activating melanocortin receptors (MC-R). However, the role of α-MSH and its possible target receptors in the heart remain completely unknown. Here we...
3.
Pohjolainen L, Kinnunen S, Auno S, Kiriazis A, Pohjavaara S, Kari-Koskinen J, et al.
Stem Cell Res Ther
. 2024 Jan;
15(1):5.
PMID: 38167208
Background: The prevalence of heart failure is constantly increasing, and the prognosis of patients remains poor. New treatment strategies to preserve cardiac function and limit cardiac hypertrophy are therefore urgently...
4.
Chaudhari U, Pohjolainen L, Ruskoaho H, Talman V
Front Cardiovasc Med
. 2023 Jun;
10:1148618.
PMID: 37283582
Background: After birth, mammalian cardiomyocytes substantially lose proliferative capacity with a concomitant switch from glycolytic to oxidative mitochondrial energy metabolism. Micro-RNAs (miRNAs) regulate gene expression and thus control various cellular...
5.
Huethorst E, Mortensen P, Simitev R, Gao H, Pohjolainen L, Talman V, et al.
J Physiol
. 2021 Nov;
600(3):483-507.
PMID: 34761809
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) in monolayers interact mechanically via cell-cell and cell-substrate adhesion. Spatiotemporal features of contraction were analysed in hiPSC-CM monolayers (1) attached to glass or...
6.
Hlushchuk I, Ruskoaho H, Domanskyi A, Airavaara M, Valimaki M
ACS Chem Neurosci
. 2021 Jun;
12(13):2273-2279.
PMID: 34110772
Neurodegenerative diseases are associated with failed proteostasis and accumulation of insoluble protein aggregates that compromise neuronal function and survival. In Parkinson's disease, a major pathological finding is Lewy bodies and...
7.
Valimaki M, Leigh R, Kinnunen S, March A, Hernandez de Sande A, Kinnunen M, et al.
Stem Cell Res Ther
. 2021 Mar;
12(1):190.
PMID: 33736688
Background: Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. Compounds that target tissue-specific transcription factors could overcome non-specific effects...
8.
Pohjolainen L, Easton J, Solanki R, Ruskoaho H, Talman V
Front Pharmacol
. 2021 Feb;
11:553852.
PMID: 33584253
Hypertrophy of cardiomyocytes (CMs) is initially a compensatory mechanism to cardiac overload, but when prolonged, it leads to maladaptive myocardial remodeling, impairing cardiac function and causing heart failure. A key...
9.
Karhu S, Ruskoaho H, Talman V
Mol Pharmacol
. 2020 Nov;
99(2):104-113.
PMID: 33239332
Cardiac fibrosis is characterized by accumulation and activation of fibroblasts and excessive production of extracellular matrix, which results in myocardial stiffening and eventually leads to heart failure. Although previous work...
10.
Fernandez C, Rysa J, Strom K, Nilsson J, Engstrom G, Orho-Melander M, et al.
ESC Heart Fail
. 2020 May;
7(4):1891-1899.
PMID: 32410391
Aims: Hypertension is the leading cause for the development of heart failure (HF). Here, we aimed to identify cardiomyocyte stretch-induced circulating biomarkers for predicting hypertension-associated HF. Methods And Results: Circulating...