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Vincenzo Crunelli

Explore the profile of Vincenzo Crunelli including associated specialties, affiliations and a list of published articles. Areas
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Articles 105
Citations 3810
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Recent Articles
1.
Casarrubea M, Radic M, Morais T, Mifsud E, Cuboni E, Aiello S, et al.
CNS Neurosci Ther . 2023 Sep; 30(3):e14443. PMID: 37658671
Aim: The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are an inbred polygenic model of childhood absence epilepsy (CAE), which, as their non-epileptic control (NEC) rats, are derived from Wistar...
2.
Neuparth-Sottomayor M, Pina C, Morais T, Farinha-Ferreira M, Abreu D, Solano F, et al.
Neurobiol Dis . 2023 Aug; 186:106275. PMID: 37648038
Typical absence seizures (ASs) are brief periods of lack of consciousness, associated with 2.5-4 Hz spike-wave discharges (SWDs) in the EEG, which are highly prevalent in children and teenagers. The...
3.
Dervinis M, Crunelli V
CNS Neurosci Ther . 2023 Apr; 30(3):e14206. PMID: 37072918
Aim: Many biophysical and non-biophysical models have been able to reproduce the corticothalamic activities underlying different EEG sleep rhythms but none of them included the known ability of neocortical networks...
4.
Dervinis M, Crunelli V
CNS Neurosci Ther . 2023 Apr; 30(3):e14204. PMID: 37032628
Aims: Recurrent network activity in corticothalamic circuits generates physiological and pathological EEG waves. Many computer models have simulated spike-and-wave discharges (SWDs), the EEG hallmark of absence seizures (ASs). However, these...
5.
Crunelli V, David F, Morais T, Lorincz M
Neurobiol Dis . 2023 Mar; 181:106107. PMID: 37001612
Hyperpolarization-activation cyclic nucleotide-gated (HCN) channels were for the first time implicated in absence seizures (ASs) when an abnormal I (the current generated by these channels) was reported in neocortical layer...
6.
Atherton Z, Nagy O, Barcsai L, Sere P, Zsigri N, Foldi T, et al.
Neurobiol Dis . 2023 Feb; 178:106025. PMID: 36731682
Spike-and-wave discharges (SWDs), generated by the cortico-thalamo-cortical (CTC) network, are pathological, large amplitude oscillations and the hallmark of absence seizures (ASs). SWDs begin in a cortical initiation network in both...
7.
McCafferty C, Gruenbaum B, Tung R, Li J, Zheng X, Salvino P, et al.
Nat Commun . 2023 Jan; 14(1):117. PMID: 36627270
Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake female rat model recapitulates the behavioral, electroencephalographic, and...
8.
Roebber J, Lewis P, Crunelli V, Navarrete M, Hamandi K
Brain Sci . 2022 Oct; 12(10). PMID: 36291222
There is a close bidirectional relationship between sleep and epilepsy. Anti-seizure medications (ASM) act to reduce seizure frequency but can also impact sleep; this remains a relatively unexplored field given...
9.
De Deurwaerdere P, Casarrubea M, Cassar D, Radic M, Puginier E, Chagraoui A, et al.
Front Cell Neurosci . 2022 Jun; 16:886033. PMID: 35677756
Childhood absence epilepsy (CAE) is characterized by absence seizures, which are episodes of lack of consciousness accompanied by electrographic spike-wave discharges. About 60% of children and adolescents with absence seizures...
10.
Cassar D, Radic M, Casarrubea M, Crunelli V, Di Giovanni G
CNS Neurosci Ther . 2022 Apr; 28(8):1268-1270. PMID: 35470960
GAERS and NEC rats were treated with cannabinoid 1/2 receptor agonist WIN 55,212-2 2 mg/kg and tested on the Elevated Plus-Maze.