Stuart W Hughes
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Explore the profile of Stuart W Hughes including associated specialties, affiliations and a list of published articles.
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33
Citations
2105
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Recent Articles
1.
Aggarwal J, Liu W, Montandon G, Liu H, Hughes S, Horner R
Sci Rep
. 2020 Jan;
10(1):550.
PMID: 31953471
Motoneurons are the final output pathway for the brain's influence on behavior. Here we identify properties of hypoglossal motor output to the tongue musculature. Tongue motor control is critical to...
2.
Crunelli V, Lorincz M, Connelly W, David F, Hughes S, Lambert R, et al.
Nat Rev Neurosci
. 2018 Jan;
19(2):107-118.
PMID: 29321683
During inattentive wakefulness and non-rapid eye movement (NREM) sleep, the neocortex and thalamus cooperatively engage in rhythmic activities that are exquisitely reflected in the electroencephalogram as distinctive rhythms spanning a...
3.
Lorincz M, Gunner D, Bao Y, Connelly W, Isaac J, Hughes S, et al.
J Neurosci
. 2015 Apr;
35(14):5442-58.
PMID: 25855163
During sleep and anesthesia, neocortical neurons exhibit rhythmic UP/DOWN membrane potential states. Although UP states are maintained by synaptic activity, the mechanisms that underlie the initiation and robust rhythmicity of...
4.
Crunelli V, David F, Lorincz M, Hughes S
Curr Opin Neurobiol
. 2014 Sep;
31:72-80.
PMID: 25233254
During non-REM sleep the EEG is dominated by slow waves which result from synchronized UP and DOWN states in the component neurons of the thalamocortical network. This review focuses on...
5.
Grace K, Hughes S, Horner R
Sleep
. 2014 Jan;
37(1):41-50.
PMID: 24470694
Study Objectives: Obstructive sleep apnea (OSA) is a significant public health problem caused by repeated episodes of upper airway closure that occur only during sleep. Attempts to treat OSA pharmacologically...
6.
Gardner R, Hughes S, Jones M
J Neurosci
. 2013 Nov;
33(47):18469-80.
PMID: 24259570
The 8-15 Hz thalamocortical oscillations known as sleep spindles are a universal feature of mammalian non-REM sleep, during which they are presumed to shape activity-dependent plasticity in neocortical networks. The...
7.
Horner R, Hughes S, Malhotra A
J Appl Physiol (1985)
. 2013 Aug;
116(3):325-36.
PMID: 23970535
The root cause of the most common and serious of the sleep disorders is impairment of breathing, and a number of factors predispose a particular individual to hypoventilation during sleep....
8.
K+ channel modulation causes genioglossus inhibition in REM sleep and is a strategy for reactivation
Grace K, Hughes S, Shahabi S, Horner R
Respir Physiol Neurobiol
. 2013 Jul;
188(3):277-88.
PMID: 23872455
Rapid eye movement (REM) sleep is accompanied by periods of upper airway motor suppression that cause hypoventilation and obstructive apneas in susceptible individuals. A common idea has been that upper...
9.
Grace K, Hughes S, Horner R
Am J Respir Crit Care Med
. 2012 Dec;
187(3):311-9.
PMID: 23220910
Rationale: Inhibition of pharyngeal motoneurons accompanies REM sleep and is a cause of hypoventilation and obstructive sleep apnea in humans. One explanation posits that the neurotransmitters glycine and γ-aminobutyric acid...
10.
Errington A, Hughes S, Crunelli V
J Physiol
. 2012 May;
590(16):3691-700.
PMID: 22641775
The distribution of T-type Ca2+ channels along the entire somatodendritic axis of sensory thalamocortical (TC) neurons permits regenerative propagation of low threshold spikes (LTS) accompanied by global dendritic Ca2+ influx....