Vincent Paupe
Overview
Explore the profile of Vincent Paupe including associated specialties, affiliations and a list of published articles.
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19
Citations
1387
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0
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Recent Articles
1.
Tabara L, Burr S, Frison M, Chowdhury S, Paupe V, Nie Y, et al.
Cell
. 2024 Jun;
187(14):3619-3637.e27.
PMID: 38851188
Mitochondrial dynamics play a critical role in cell fate decisions and in controlling mtDNA levels and distribution. However, the molecular mechanisms linking mitochondrial membrane remodeling and quality control to mtDNA...
2.
Wilson E, Yu Y, Leal N, Woodward J, Patikas N, Morris J, et al.
Cell Death Dis
. 2024 Mar;
15(3):203.
PMID: 38467609
Organelles form membrane contact sites between each other, allowing for the transfer of molecules and signals. Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are cellular subdomains characterized by close apposition of...
3.
Zecchini V, Paupe V, Herranz-Montoya I, Janssen J, Wortel I, Morris J, et al.
Nature
. 2023 Mar;
615(7952):499-506.
PMID: 36890229
Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through the accumulation of the oncometabolite fumarate....
4.
Tilokani L, Russell F, Hamilton S, Virga D, Segawa M, Paupe V, et al.
Sci Adv
. 2022 Nov;
8(45):eabo7956.
PMID: 36367943
Mitochondria are dynamic organelles that undergo membrane remodeling events in response to metabolic alterations to generate an adequate mitochondrial network. Here, we investigated the function of mitochondrial fission regulator 1-like...
5.
Lisci M, Barton P, Randzavola L, Ma C, Marchingo J, Cantrell D, et al.
Science
. 2021 Oct;
374(6565):eabe9977.
PMID: 34648346
T cell receptor activation of naïve CD8 T lymphocytes initiates their maturation into effector cytotoxic T lymphocytes (CTLs), which can kill cancer and virally infected cells. Although CTLs show an...
6.
Nagashima S, Tabara L, Tilokani L, Paupe V, Anand H, Pogson J, et al.
Science
. 2020 Mar;
367(6484):1366-1371.
PMID: 32193326
Mitochondrial plasticity is a key regulator of cell fate decisions. Mitochondrial division involves Dynamin-related protein-1 (Drp1) oligomerization, which constricts membranes at endoplasmic reticulum (ER) contact sites. The mechanisms driving the...
7.
Tilokani L, Nagashima S, Paupe V, Prudent J
Essays Biochem
. 2018 Jul;
62(3):341-360.
PMID: 30030364
Mitochondria are highly dynamic organelles undergoing coordinated cycles of fission and fusion, referred as 'mitochondrial dynamics', in order to maintain their shape, distribution and size. Their transient and rapid morphological...
8.
Paupe V, Prudent J
Biochem Biophys Res Commun
. 2017 May;
500(1):75-86.
PMID: 28495532
Mitochondria are dynamic organelles involved in numerous physiological functions. Beyond their function in ATP production, mitochondria regulate cell death, reactive oxygen species (ROS) generation, immunity and metabolism. Mitochondria also play...
9.
Janer A, Prudent J, Paupe V, Fahiminiya S, Majewski J, Sgarioto N, et al.
EMBO Mol Med
. 2016 Jul;
8(9):1019-38.
PMID: 27390132
Mitochondria form a dynamic network that responds to physiological signals and metabolic stresses by altering the balance between fusion and fission. Mitochondrial fusion is orchestrated by conserved GTPases MFN1/2 and...
10.
Paupe V, Prudent J, Dassa E, Zurita Rendon O, Shoubridge E
Cell Metab
. 2015 Jan;
21(1):109-16.
PMID: 25565209
Mitochondrial calcium is an important modulator of cellular metabolism. CCDC90A was reported to be a regulator of the mitochondrial calcium uniporter (MCU) complex, a selective channel that controls mitochondrial calcium...