Shun Nagashima
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Explore the profile of Shun Nagashima including associated specialties, affiliations and a list of published articles.
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31
Citations
1188
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Recent Articles
1.
Shiiba I, Ito N, Oshio H, Ishikawa Y, Nagao T, Shimura H, et al.
Nat Commun
. 2025 Feb;
16(1):1508.
PMID: 39929810
The proximal domains of mitochondria and the endoplasmic reticulum (ER) are linked by tethering factors on each membrane, allowing the efficient transport of substances, including lipids and calcium, between them....
2.
Tanabe M, Saito Y, Takasaki A, Nakano K, Yamamoto S, Suzuki C, et al.
Cell Rep
. 2024 Dec;
44(1):115133.
PMID: 39731733
During gestation, the choroid plexus (ChP) produces protein-rich cerebrospinal fluid and matures prior to brain development. It is assumed that ChP dysfunction has a profound effect on developmental neuropsychiatric disorders,...
3.
Shimura H, Yamamoto S, Shiiba I, Oikawa M, Uchinomiya S, Ojida A, et al.
J Biochem
. 2024 Dec;
177(3):203-212.
PMID: 39727324
Brown adipocytes are characterized by a high abundance of mitochondria, allowing them to consume fatty acids for heat production. Increasing the number of brown adipocytes is considered a promising strategy...
4.
Oi A, Shinoda N, Nagashima S, Miura M, Obata F
Cell Rep
. 2024 Dec;
44(1):115082.
PMID: 39719708
An excessive immune response damages organs, yet its molecular mechanism is incompletely understood. Here, we screened a factor mediating organ damage upon genetic activation of the innate immune pathway using...
5.
Zecchini V, Paupe V, Herranz-Montoya I, Janssen J, Wortel I, Morris J, et al.
Nature
. 2023 Mar;
615(7952):499-506.
PMID: 36890229
Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through the accumulation of the oncometabolite fumarate....
6.
Nagashima S, Ito N, Shiiba I, Shimura H, Yanagi S
J Biochem
. 2022 Nov;
173(1):1-11.
PMID: 36346121
Mitochondria are involved in various cellular processes, such as energy production, inflammatory responses and cell death. Mitochondrial dysfunction is associated with many age-related diseases, including neurological disorders and heart failure....
7.
Tokuyama T, Uosaki H, Sugiura A, Nishitai G, Takeda K, Nagashima S, et al.
iScience
. 2022 Jul;
25(7):104582.
PMID: 35789860
Abnormal mitochondrial fragmentation by dynamin-related protein1 (Drp1) is associated with the progression of aging-associated heart diseases, including heart failure and myocardial infarction (MI). Here, we report a protective role of...
8.
Ito N, Takahashi T, Shiiba I, Nagashima S, Inatome R, Yanagi S
J Biochem
. 2021 Dec;
171(5):529-541.
PMID: 34964862
The transfer of phospholipids from the endoplasmic reticulum (ER) to mitochondria via the mitochondria-ER contact site (MERCS) is essential for maintaining mitochondrial function and integrity. Here, we identified RMDN3/PTPIP51, possessing...
9.
Okuda S, Sato M, Kato S, Nagashima S, Inatome R, Yanagi S, et al.
J Biol Chem
. 2021 Jul;
297(2):100986.
PMID: 34298015
Radial migration during cortical development is required for formation of the six-layered structure of the mammalian cortex. Defective migration of neurons is linked to several developmental disorders such as autism...
10.
Nagashima S, Ito N, Kobayashi R, Shiiba I, Shimura H, Fukuda T, et al.
J Biol Chem
. 2021 Apr;
296:100620.
PMID: 33811862
Mouse models of various neuropsychiatric disorders, such as schizophrenia, often display an immature dentate gyrus, characterized by increased numbers of immature neurons and neuronal progenitors and a dearth of mature...