Vincent M Loh Jr
Overview
Explore the profile of Vincent M Loh Jr including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
241
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Recent Articles
1.
Menear K, Adcock C, Boulter R, Cockcroft X, Copsey L, Cranston A, et al.
J Med Chem
. 2008 Sep;
51(20):6581-91.
PMID: 18800822
Poly(ADP-ribose) polymerase activation is an immediate cellular response to metabolic-, chemical-, or ionizing radiation-induced DNA damage and represents a new target for cancer therapy. In this article, we disclose a...
2.
Cockcroft X, Dillon K, Dixon L, Drzewiecki J, Kerrigan F, Loh Jr V, et al.
Bioorg Med Chem Lett
. 2005 Nov;
16(4):1040-4.
PMID: 16290932
We have previously described the discovery of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors based on a phthalazinone scaffold. Subsequent optimisation of inhibitory activity, metabolic stability and pharmacokinetic parameters has led to a novel...
3.
Loh Jr V, Cockcroft X, Dillon K, Dixon L, Drzewiecki J, Eversley P, et al.
Bioorg Med Chem Lett
. 2005 Apr;
15(9):2235-8.
PMID: 15837300
Screening of the Maybridge compound collection identified 4-arylphthalazinones as micromolar inhibitors of PARP-1 catalytic activity. Subsequent optimisation of both inhibitory activity and metabolic stability led to a novel series of...