Vincent Larraillet
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Explore the profile of Vincent Larraillet including associated specialties, affiliations and a list of published articles.
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14
Citations
218
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Recent Articles
1.
Bauer N, Boettger M, Papadaki S, Leitner T, Klostermann S, Kettenberger H, et al.
Front Bioeng Biotechnol
. 2024 Nov;
12:1414408.
PMID: 39530057
We present a detailed mass spectrometric analysis of three 2 + 1 T-cell bispecific monoclonal antibodies (TCB mAbs), where an unexpected +15.9950 Da mass shift in tryptic peptides was observed....
2.
Vasic V, Dickopf S, Spranger N, Rosenberger R, Fischer M, Mayer K, et al.
Nat Commun
. 2024 Oct;
15(1):9406.
PMID: 39477939
The generation of antibody-drug conjugates with optimal functionality depends on many parameters. These include binder epitope, antibody format, linker composition, conjugation site(s), drug-to-antibody ratio, and conjugation method. The production of...
3.
Kufer R, Larraillet V, Thalhauser S, Graf T, Endesfelder M, Wohlrab S
J Pharm Sci
. 2023 Dec;
113(6):1470-1477.
PMID: 38135055
Host cell protein (HCP) characterization is a crucial quality parameter for biotherapeutic drug safety and stability. With a liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach, we identified ubiquitin in ultrafiltration/diafiltration (UF/DF)...
4.
Duivelshof B, Bouvarel T, Pirner S, Larraillet V, Knaupp A, Koll H, et al.
Int J Mol Sci
. 2023 Dec;
24(23).
PMID: 38068945
Charge heterogeneity among therapeutic monoclonal antibodies (mAbs) is considered an important critical quality attribute and requires careful characterization to ensure safe and efficacious drug products. The charge heterogeneity among mAbs...
5.
Murisier A, DAtri V, Pirner S, Larraillet V, Fekete S, Lauber M, et al.
Pharmaceutics
. 2022 Nov;
14(11).
PMID: 36365134
This work illustrates the benefits and limitations of using ultra-short reversed phase liquid chromatography (RPLC) columns for the characterization of various complex bispecific antibodies after prolonged thermal stress at the...
6.
Schneider A, Gorr I, Larraillet V, Frensing T, Popp O
Biotechnol Bioeng
. 2019 Jun;
116(10):2503-2513.
PMID: 31180133
Interleukin-2 (IL-2) is a potent molecule in cancer therapy. Clinical application, however, is limited due to its strong side effects during the treatment. We developed an IL-2 variant (IL-2v) immunocytokine...
7.
Jensen P, Schoch A, Larraillet V, Hilger M, Schlothauer T, Emrich T, et al.
Mol Cell Proteomics
. 2017 Jan;
16(3):451-456.
PMID: 28062799
The success of recombinant monoclonal immunoglobulins (IgG) is rooted in their ability to target distinct antigens with high affinity combined with an extraordinarily long serum half-life, typically around 3 weeks....
8.
Walters B, Jensen P, Larraillet V, Lin K, Patapoff T, Schlothauer T, et al.
J Biol Chem
. 2015 Dec;
291(4):1817-1825.
PMID: 26627822
Crystallographic evidence suggests that the pH-dependent affinity of IgG molecules for the neonatal Fc receptor (FcRn) receptor primarily arises from salt bridges involving IgG histidine residues, resulting in moderate affinity...
9.
Popp O, Larraillet V, Kettenberger H, Gorr I, Hilger M, Lipsmeier F, et al.
Biotechnol Bioeng
. 2014 Dec;
112(6):1187-99.
PMID: 25545851
In-depth analytical characterization of biotherapeutics originating from different production batches is mandatory to ensure product safety and consistent molecule efficacy. Previously, we have shown unintended incorporation of tyrosine (Tyr) and...
10.
Jensen P, Larraillet V, Schlothauer T, Kettenberger H, Hilger M, Rand K
Mol Cell Proteomics
. 2014 Nov;
14(1):148-61.
PMID: 25378534
The recycling of immunoglobulins by the neonatal Fc receptor (FcRn) is of crucial importance in the maintenance of antibody levels in plasma and is responsible for the long half-lives of...