Vince A Chiodo
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Explore the profile of Vince A Chiodo including associated specialties, affiliations and a list of published articles.
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44
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2498
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Recent Articles
1.
Nam M, Nahomi R, Pantcheva M, Dhillon A, Chiodo V, Smith W, et al.
Transl Vis Sci Technol
. 2022 Nov;
11(11):8.
PMID: 36355386
Purpose: Ocular hypertension is a significant risk factor for vision loss in glaucoma caused by the death of retinal ganglion cells (RGCs). We investigated whether small heat shock proteins (sHsps)...
2.
Roddy G, Chowdhury U, Anderson K, Rinkoski T, Hann C, Chiodo V, et al.
PLoS One
. 2022 May;
17(5):e0269261.
PMID: 35639753
Glaucoma is the leading cause of irreversible blindness worldwide. Therapies for glaucoma are directed toward reducing intraocular pressure (IOP), the leading risk factor and only reliable therapeutic target via topical...
3.
Goodson N, Park K, Silver J, Chiodo V, Hauswirth W, Brzezinski 4th J
Dev Biol
. 2020 Jun;
464(2):111-123.
PMID: 32562755
The transcription factors Prdm1 (Blimp1) and Vsx2 (Chx10) work downstream of Otx2 to regulate photoreceptor and bipolar cell fates in the developing retina. Mice that lack Vsx2 fail to form...
4.
Dyka F, Molday L, Chiodo V, Molday R, Hauswirth W
Hum Gene Ther
. 2019 Aug;
30(11):1361-1370.
PMID: 31418294
Autosomal recessive Stargardt disease is the most common inherited macular degeneration in humans. It is caused by mutations in the retina-specific ATP binding cassette transporter A4 (ABCA4) that is essential...
5.
Hanke-Gogokhia C, Chiodo V, Hauswirth W, Frederick J, Baehr W
Mol Vis
. 2019 Feb;
24:834-846.
PMID: 30713422
Purpose: Recessive mutations in the human gene are associated with Senior-Løken syndrome (SLS), a ciliopathy presenting with nephronophthisis and Leber congenital amaurosis (LCA). -knockout mice develop LCA without nephronophthisis. Mutant...
6.
Bosco A, Anderson S, Breen K, Romero C, Steele M, Chiodo V, et al.
Mol Ther
. 2018 Sep;
26(10):2379-2396.
PMID: 30217731
Dysregulation of the complement system is implicated in neurodegeneration, including human and animal glaucoma. Optic nerve and retinal damage in glaucoma is preceded by local complement upregulation and activation, but...
7.
Deng W, Kolandaivelu S, Dinculescu A, Li J, Zhu P, Chiodo V, et al.
Front Mol Neurosci
. 2018 Jul;
11:233.
PMID: 30038560
Rod and cone phosphodiesterase 6 (PDE6) are key effector enzymes of the vertebrate phototransduction pathway. Rod PDE6 consists of two catalytic subunits PDE6α and PDE6β and two identical inhibitory PDE6γ...
8.
Guziewicz K, Cideciyan A, Beltran W, Komaromy A, Dufour V, Swider M, et al.
Proc Natl Acad Sci U S A
. 2018 Mar;
115(12):E2839-E2848.
PMID: 29507198
Mutations in the gene cause detachment of the retina and degeneration of photoreceptor (PR) cells due to a primary channelopathy in the neighboring retinal pigment epithelium (RPE) cells. The pathophysiology...
9.
Deng W, Li J, Zhu P, Chiodo V, Smith W, Freedman B, et al.
Mol Vis
. 2018 Feb;
24:17-28.
PMID: 29386880
Purpose: Blue cone monochromacy (BCM) is an X-linked congenital vision disorder characterized by complete loss or severely reduced L- and M-cone function. Patients with BCM display poor visual acuity, severely...
10.
Kady N, Liu X, Lydic T, Syed M, Navitskaya S, Wang Q, et al.
Diabetes
. 2018 Jan;
67(4):769-781.
PMID: 29362226
Tight junctions (TJs) involve close apposition of transmembrane proteins between cells. Although TJ proteins have been studied in detail, the role of lipids is largely unknown. We addressed the role...