Vinagolu K Rajasekhar
Overview
Explore the profile of Vinagolu K Rajasekhar including associated specialties, affiliations and a list of published articles.
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40
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5907
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Recent Articles
1.
Cai W, Tanaka K, Mi X, Rajasekhar V, Khan J, Yoo S, et al.
Cancer Immunol Res
. 2024 Jul;
12(10):1361-1379.
PMID: 38959337
Chimeric antigen receptor (CAR) T-cell therapy has resulted in remarkable clinical success in the treatment of B-cell malignancies. However, its clinical efficacy in solid tumors is limited, primarily by target...
2.
Bojmar L, Zambirinis C, Hernandez J, Chakraborty J, Shaashua L, Kim J, et al.
Nat Med
. 2024 Jun;
30(8):2170-2180.
PMID: 38942992
Metastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we hypothesized that multi-parametric analysis of pre-metastatic liver biopsies would classify patients according to their metastatic risk, timing...
3.
Shi Y, Kotchetkov I, Dobrin A, Hanina S, Rajasekhar V, Healey J, et al.
Mol Ther
. 2024 May;
32(7):2393-2405.
PMID: 38720457
The tumor microenvironment presents many obstacles to effective chimeric antigen receptor (CAR) T cell therapy, including glucose competition from tumor and myeloid cells. Using mouse models of acute lymphoblastic leukemia...
4.
Ben-Chetrit N, Niu X, Sotelo J, Swett A, Rajasekhar V, Jiao M, et al.
bioRxiv
. 2023 Nov;
PMID: 37961223
Tumor-infiltrating macrophages support critical steps in tumor progression, and their accumulation in the tumor microenvironment (TME) is associated with adverse outcomes and therapeutic resistance across human cancers. In the TME,...
5.
Wang G, Li J, Bojmar L, Chen H, Li Z, Tobias G, et al.
Nature
. 2023 May;
618(7964):374-382.
PMID: 37225988
Cancer alters the function of multiple organs beyond those targeted by metastasis. Here we show that inflammation, fatty liver and dysregulated metabolism are hallmarks of systemically affected livers in mouse...
6.
Strillacci A, Sansone P, Rajasekhar V, Turkekul M, Boyko V, Meng F, et al.
NPJ Breast Cancer
. 2022 Aug;
8(1):96.
PMID: 35999225
Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions. Therapeutic targeting of the hormone...
7.
Joshi S, Gomes E, Wang T, Corben A, Taldone T, Gandu S, et al.
Commun Biol
. 2021 Nov;
4(1):1333.
PMID: 34824367
Cancer cell plasticity due to the dynamic architecture of interactome networks provides a vexing outlet for therapy evasion. Here, through chemical biology approaches for systems level exploration of protein connectivity...
8.
Fujiwara T, Yakoub M, Chandler A, Christ A, Yang G, Ouerfelli O, et al.
Mol Cancer Ther
. 2021 Jun;
20(8):1388-1399.
PMID: 34088832
Colony-stimulating factor 1 (CSF1) is a primary regulator of the survival, proliferation, and differentiation of monocyte/macrophage that sustains the protumorigenic functions of tumor-associated macrophages (TAMs). Considering current advances in understanding...
9.
Wojnarowicz P, Escolano M, Huang Y, Desai B, Chin Y, Shah R, et al.
NPJ Breast Cancer
. 2021 May;
7(1):58.
PMID: 34031428
ID proteins are helix-loop-helix (HLH) transcriptional regulators frequently overexpressed in cancer. ID proteins inhibit basic-HLH transcription factors often blocking differentiation and sustaining proliferation. A small-molecule, AGX51, targets ID proteins for...
10.
Hoshino A, Kim H, Bojmar L, Gyan K, Cioffi M, Hernandez J, et al.
Cell
. 2020 Aug;
182(4):1044-1061.e18.
PMID: 32795414
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in 426 human...