Viktor H Koelzer
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Explore the profile of Viktor H Koelzer including associated specialties, affiliations and a list of published articles.
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97
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2994
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Recent Articles
1.
Schoenpflug L, Chatzipli A, Sirinukunwattana K, Richman S, Blake A, Robineau J, et al.
J Pathol
. 2024 Dec;
265(2):184-197.
PMID: 39710952
Tumour content plays a pivotal role in directing the bioinformatic analysis of molecular profiles such as copy number variation (CNV). In clinical application, tumour purity estimation (TPE) is achieved either...
2.
Andani S, Chen B, Ficek-Pascual J, Heinke S, Casanova R, Hild B, et al.
medRxiv
. 2024 Dec;
PMID: 39677425
Multiplexed imaging technologies provide crucial insights into interactions between tumors and their surrounding tumor microenvironment (TME), but their widespread adoption is limited by cost, time, and tissue availability. We introduce...
3.
Schoenpflug L, Nie Y, Sheikhzadeh F, Koelzer V
Comput Struct Biotechnol J
. 2024 Nov;
23:3938-3945.
PMID: 39582895
Training generalizable computational pathology (CPATH) algorithms is heavily dependent on large-scale, multi-institutional data. Simultaneously, healthcare data underlies strict data privacy rules, hindering the creation of large datasets. Federated Learning (FL)...
4.
Wegmann R, Bonilla X, Casanova R, Chevrier S, Coelho R, Esposito C, et al.
Nat Commun
. 2024 Oct;
15(1):9402.
PMID: 39477946
Deep single-cell multi-omic profiling offers a promising approach to understand and overcome drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML). Here, we combine single-cell ex vivo drug...
5.
Wu J, Koelzer V
Comput Struct Biotechnol J
. 2024 Oct;
23:3481-3488.
PMID: 39435342
Digital twins in biomedical research, i.e. virtual replicas of biological entities such as cells, organs, or entire organisms, hold great potential to advance personalized healthcare. As all biological processes happen...
6.
Nowak M, Jabbar F, Rodewald A, Gneo L, Tomasevic T, Harkin A, et al.
Cell Rep Med
. 2024 Sep;
5(9):101727.
PMID: 39293403
Testing for DNA mismatch repair deficiency (MMRd) is recommended for all colorectal cancers (CRCs). Automating this would enable precision medicine, particularly if providing information on etiology not captured by deep...
7.
Rubin D, Kubassova O, Weber C, Adsul S, Freire M, Biedermann L, et al.
Inflamm Bowel Dis
. 2024 Sep;
PMID: 39284932
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by increased stool frequency, rectal bleeding, and urgency. To streamline the quantitative assessment of histopathology using the Nancy Index...
8.
Vledder A, Paijens S, Loiero D, Maagdenberg A, Duiker E, Bart J, et al.
Int J Cancer
. 2024 Aug;
155(12):2265-2276.
PMID: 39175107
Recent work has shown evidence for the prognostic significance of tumor infiltrating B cells (B-TIL) in high grade serous ovarian carcinoma (HGSOC), the predominant histological subtype of ovarian cancer. However,...
9.
Mahmood U, Blake A, Rathee S, Samuel L, Murray G, Sebag-Montefiore D, et al.
Cancer Res Commun
. 2024 Jul;
4(7):1765-1776.
PMID: 39023969
Significance: Rectal cancers with stromal features may respond better to RT and 5FU/Cap with the addition of Ox. Within patients not treated with Ox, high levels of cytotoxic lymphocytes associate...
10.
Wu J, Koelzer V
Comput Biol Med
. 2024 Jul;
179:108825.
PMID: 39002318
Background: Modeling heterogeneous disease states by data-driven methods has great potential to advance biomedical research. However, a comprehensive analysis of phenotypic heterogeneity is often challenged by the complex nature of...