Vikash Sinha
Overview
Explore the profile of Vikash Sinha including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
151
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0
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Recent Articles
11.
Salih H, Anghelescu I, Kezic I, Sinha V, Hoeben E, van Nueten L, et al.
J Psychopharmacol
. 2015 Mar;
29(4):414-25.
PMID: 25735992
Metabotropic glutamate receptor-2 positive allosteric modulator, JNJ-40411813 (ADX71149), was characterised for clinical effects in healthy volunteers in two phase-1 studies. In study 1, healthy men received 50-, 100-, 150- or...
12.
Loryan I, Sinha V, Mackie C, Van Peer A, Drinkenburg W, Vermeulen A, et al.
Mol Pharm
. 2014 Dec;
12(2):520-32.
PMID: 25496026
In the present work we sought to gain a mechanistic understanding of the physicochemical properties that influence the transport of unbound drug across the blood-brain barrier (BBB) as well as...
13.
Loryan I, Sinha V, Mackie C, Van Peer A, Drinkenburg W, Vermeulen A, et al.
Pharm Res
. 2014 Mar;
31(8):2203-19.
PMID: 24623476
Purpose: The current project was undertaken with the aim to propose and test an in-depth integrative analysis of neuropharmacokinetic (neuroPK) properties of new chemical entities (NCEs), thereby optimizing the routine...
14.
Sinha V, Vence L, Salahudeen A
J Investig Med
. 2013 Jan;
61(3):564-8.
PMID: 23360846
Background: Several biomarkers are becoming available for the early detection of acute kidney injury (AKI), but few have been directly compared. Objective: To compare urinary kidney injury molecule-1 (KIM-1), neutrophil...
15.
Van den Bergh A, Sinha V, Gilissen R, Straetemans R, Wuyts K, Morrison D, et al.
Clin Pharmacokinet
. 2011 Jul;
50(8):505-17.
PMID: 21740074
Background And Objectives: Empirically based methods remain one of our tools in human pharmacokinetic predictions. The Dedrick approach and the steady-state plasma drug concentration (C(ss))-mean residence time (MRT) approach are...