Vikas K Verma
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Explore the profile of Vikas K Verma including associated specialties, affiliations and a list of published articles.
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13
Citations
919
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Recent Articles
1.
He L, Sehrawat T, Verma V, Navarro-Corcuera A, Sidhu G, Mauer A, et al.
Front Physiol
. 2021 May;
12:664222.
PMID: 34025452
Alcohol-associated liver disease (ALD) has been recognized as the most common cause of advanced liver disease worldwide, though mechanisms of pathogenesis remain incompletely understood. The X-linked inhibitor of apoptosis (XIAP)...
2.
Arab J, Cabrera D, Sehrawat T, Jalan-Sakrikar N, Verma V, Simonetto D, et al.
J Hepatol
. 2020 Feb;
73(1):149-160.
PMID: 32087348
Background & Aims: Steatohepatitis drives fibrogenesis in alcohol-related liver disease. Recent studies have suggested that hepatic stellate cells (HSCs) may regulate the parenchymal cell injury and inflammation that precedes liver...
3.
Arab J, Sehrawat T, Simonetto D, Verma V, Feng D, Tang T, et al.
Hepatology
. 2019 Nov;
72(2):441-453.
PMID: 31774566
Background And Aims: Interleukin-22 has beneficial effects on inflammation and impaired hepatic regeneration that characterize alcohol-associated hepatitis (AH). F-652 is a recombinant fusion protein of human interleukin-22 and immunoglobulin G2...
4.
Martin-Mateos R, de Assuncao T, Arab J, Jalan-Sakrikar N, Yaqoob U, Greuter T, et al.
Cell Mol Gastroenterol Hepatol
. 2018 Dec;
7(1):197-209.
PMID: 30539787
Background & Aims: Transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in the pathogenesis of liver fibrosis. Transforming growth factor β (TGF-β) and platelet-derived growth factor...
5.
Kostallari E, Hirsova P, Prasnicka A, Verma V, Yaqoob U, Wongjarupong N, et al.
Hepatology
. 2018 Jan;
68(1):333-348.
PMID: 29360139
Conclusion: PDGFRα is enriched in EVs derived from PDGF-BB-treated HSCs in an Src homology 2 domain tyrosine phosphatase 2-dependent manner and these PDGFRα-enriched EVs participate in development of liver fibrosis....
6.
Drinane M, Yaqoob U, Yu H, Luo F, Greuter T, Arab J, et al.
JCI Insight
. 2017 Dec;
2(24).
PMID: 29263300
The scaffold protein synectin plays a critical role in the trafficking and regulation of membrane receptor pathways. As platelet-derived growth factor receptor (PDGFR) is essential for hepatic stellate cell (HSC)...
7.
Liu Y, Verma V, Malhi H, Gores G, Kamath P, Sanyal A, et al.
Am J Physiol Cell Physiol
. 2017 Jun;
313(3):C305-C313.
PMID: 28637673
Interleukin-22 (IL-22) is a Th17 cell hepatoprotective cytokine that is undergoing clinical trials to treat patients with alcoholic hepatitis (AH). Lipopolysaccharide (LPS) activation of macrophage is implicated in hepatocyte cell...
8.
Hirsova P, Ibrahim S, Verma V, Morton L, Shah V, LaRusso N, et al.
Hepatology
. 2016 Sep;
64(6):2219-2233.
PMID: 27628960
Extracellular vesicles (EVs) are nanometer-sized, membrane-bound vesicles released by cells into the extracellular milieu. EVs are now recognized to play a critical role in cell-to-cell communication. EVs contain important cargo...
9.
Hirsova P, Ibrahim S, Krishnan A, Verma V, Bronk S, Werneburg N, et al.
Gastroenterology
. 2016 Jan;
150(4):956-67.
PMID: 26764184
Background & Aims: Hepatocyte cellular dysfunction and death induced by lipids and macrophage-associated inflammation are characteristics of nonalcoholic steatohepatitis (NASH). The fatty acid palmitate can activate death receptor 5 (DR5)...
10.
Verma V, Li H, Wang R, Hirsova P, Mushref M, Liu Y, et al.
J Hepatol
. 2015 Dec;
64(3):651-60.
PMID: 26632633
Background & Aims: The mechanisms by which hepatocyte exposure to alcohol activates inflammatory cells such as macrophages in alcoholic liver disease (ALD) are unclear. The role of released nano-sized membrane...