Vijay N Wakchaure
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Explore the profile of Vijay N Wakchaure including associated specialties, affiliations and a list of published articles.
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11
Citations
94
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Recent Articles
1.
Luo N, Turberg M, Leutzsch M, Mitschke B, Brunen S, Wakchaure V, et al.
Nature
. 2024 Jul;
632(8026):795-801.
PMID: 39085607
Polyene cyclizations are among the most complex and challenging transformations in biology. In a single reaction step, multiple carbon-carbon bonds, ring systems and stereogenic centres are constituted from simple, acyclic...
2.
Wakchaure V, DeSnoo W, Laconsay C, Leutzsch M, Tsuji N, Tantillo D, et al.
Nature
. 2024 Jan;
625(7994):287-292.
PMID: 38200298
Asymmetric catalysis is an advanced area of chemical synthesis, but the handling of abundantly available, purely aliphatic hydrocarbons has proven to be challenging. Typically, heteroatoms or aromatic substructures are required...
3.
Schreyer L, Kaib P, Wakchaure V, Obradors C, Properzi R, Lee S, et al.
Science
. 2018 Oct;
362(6411):216-219.
PMID: 30309951
Reactions that form a product with the same reactive functionality as that of one of the starting compounds frequently end in oligomerization. As a salient example, selective aldol coupling of...
4.
Wakchaure V, List B
Angew Chem Int Ed Engl
. 2016 Nov;
55(51):15775-15778.
PMID: 27873455
A highly diastereoselective and enantioselective Brønsted acid catalyzed reductive condensation of N-H imines was developed. This reaction is catalyzed by a chiral disulfonimide (DSI), uses Hantzsch esters as a hydrogen...
5.
Tap A, Blond A, Wakchaure V, List B
Angew Chem Int Ed Engl
. 2016 Jun;
55(31):8962-5.
PMID: 27275598
Herein we describe the development of a catalytic enantioselective alkynylogous Mukaiyama aldol reaction. The reaction is catalyzed by a newly designed chiral disulfonimide and delivers chiral allenoates in high yields...
6.
Wakchaure V, Kaib P, Leutzsch M, List B
Angew Chem Int Ed Engl
. 2015 Sep;
54(40):11852-6.
PMID: 26382289
A chiral disulfonimide (DSI)-catalyzed asymmetric reduction of N-alkyl imines with Hantzsch esters as a hydrogen source in the presence of Boc2 O has been developed. The reaction delivers Boc-protected N-alkyl...
7.
Arndt H, Rizzo S, Nocker C, Wakchaure V, Milroy L, Bieker V, et al.
Chemistry
. 2015 Feb;
21(14):5311-6.
PMID: 25694199
Macrocyclic natural products (NPs) and analogues thereof often show high affinity, selectivity, and metabolic stability, and methods for the synthesis of NP-like macrocycle collections are of major current interest. We...
8.
Wakchaure V, Zhou J, Hoffmann S, List B
Angew Chem Int Ed Engl
. 2010 May;
49(27):4612-4.
PMID: 20491115
No abstract available.
9.
Wakchaure V, List B
Angew Chem Int Ed Engl
. 2010 May;
49(24):4136-9.
PMID: 20455229
No abstract available.
10.
Nugent T, El-Shazly M, Wakchaure V
J Org Chem
. 2008 Jan;
73(4):1297-305.
PMID: 18198887
Reductive amination of prochiral unhindered 2-alkanones 1 with (R)- or (S)-alpha-MBA in the presence of Yb(OAc)3 (50-110 mol %), Raney-Ni, and hydrogen (120 psi) results in increased diastereoselectivity for the...