Vidula Vachharajani
Overview
Explore the profile of Vidula Vachharajani including associated specialties, affiliations and a list of published articles.
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58
Citations
880
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Recent Articles
1.
Soranno D, Coopersmith C, Brinkworth J, Factora F, Muntean J, Mythen M, et al.
Crit Care
. 2025 Feb;
29(1):91.
PMID: 40011975
In critical illness, all elements of gut function are perturbed. Dysbiosis develops as the gut microbial community loses taxonomic diversity and new virulence factors appear. Intestinal permeability increases, allowing for...
2.
Bauer S, Wieruszewski P, Bissell Turpin B, Dugar S, Sacha G, Sato R, et al.
Shock
. 2025 Feb;
PMID: 39965613
Background: Adjunctive vasopressors are added to norepinephrine in one-third of adults with septic shock in the United States. However, effectiveness of this approach is unclear, and treatment recommendations are based...
3.
Shankar-Hari M, Francois B, Remy K, Gutierrez C, Pastores S, Daix T, et al.
JCI Insight
. 2025 Feb;
PMID: 39903535
Background: Lymphopenia and failure of lymphocytes to mount an early IFN-γ response correlate with increased mortality in COVID-19. Given the essential role of CD4 helper and CD8 cytotoxic cells in...
4.
Shrestha D, Pant B, Pant B, Roychowdhury S, Gandhirajan A, Cross E, et al.
J Leukoc Biol
. 2024 Sep;
117(2).
PMID: 39340428
Septic shock is associated with over 40% mortality. The immune response in septic shock is tightly regulated by cellular metabolism and transitions from early hyper-inflammation to later hypo-inflammation. Patients are...
5.
Orsini E, Roychowdhury S, Gangadhariah M, Cross E, Abraham S, Reinhardt A, et al.
Am J Respir Cell Mol Biol
. 2024 Feb;
70(6):457-467.
PMID: 38346220
Sepsis is a systemic inflammatory response that requires effective macrophage metabolic functions to resolve ongoing inflammation. Previous work showed that the mechanosensitive cation channel, transient receptor potential vanilloid 4 (TRPV4),...
6.
Duggal A, Scheraga R, Sacha G, Wang X, Huang S, Krishnan S, et al.
BMJ Open
. 2024 Feb;
14(2):e079243.
PMID: 38320842
Objective: Conventional prediction models fail to integrate the constantly evolving nature of critical illness. Alternative modelling approaches to study dynamic changes in critical illness progression are needed. We compare static...
7.
Roychowdhury S, Pant B, Cross E, Scheraga R, Vachharajani V
J Leukoc Biol
. 2023 Dec;
115(6):1029-1041.
PMID: 38066660
Alcohol use disorder, reported by 1 in 8 critically ill patients, is a risk factor for death in sepsis patients. Sepsis, the leading cause of death, kills over 270,000 patients...
8.
Jeng M, Orsini E, Yerke J, Mehkri O, Mireles-Cabodevila E, Khouli H, et al.
Crit Care Explor
. 2023 Nov;
5(11):e1008.
PMID: 38020848
Objectives: Diagnosis of pneumonia is challenging in critically ill, intubated patients due to limited diagnostic modalities. Endotracheal aspirate (EA) cultures are standard of care in many ICUs; however, frequent EA...
9.
Bauer S, Wieruszewski P, Bissell B, Dugar S, Sacha G, Sato R, et al.
medRxiv
. 2023 Aug;
PMID: 37546921
Background: Over one-third of patients with septic shock have adjunctive vasopressors added to first-line vasopressors. However, no randomized trial has detected improved mortality with adjunctive vasopressors. Published systematic reviews and...
10.
Kim A, Ortega-Ribera M, McMullen M, Bellar A, Taiwo M, Pathak V, et al.
iScience
. 2023 Jun;
26(7):107133.
PMID: 37361874
Alcohol abuse causes increased susceptibility to respiratory syndromes like bacterial pneumonia and viral infections like SARS-CoV-2. Heavy drinkers (HD) are at higher risk of severe COVID-19 if they are also...