Vidhya Krishnamoorthy
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Explore the profile of Vidhya Krishnamoorthy including associated specialties, affiliations and a list of published articles.
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11
Citations
760
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Recent Articles
1.
Krishnamoorthy V, Foglizzo M, Dilley R, Wu A, Datta A, Dutta P, et al.
Cell
. 2024 Mar;
187(9):2250-2268.e31.
PMID: 38554706
Ubiquitin-dependent unfolding of the CMG helicase by VCP/p97 is required to terminate DNA replication. Other replisome components are not processed in the same fashion, suggesting that additional mechanisms underlie replication...
2.
Krishnamoorthy V, Khanna R, Parnaik V
Biochem Biophys Res Commun
. 2018 Sep;
503(4):2478-2484.
PMID: 30208514
Heterochromatin protein 1 (HP1) isoforms are conserved non-histone chromatin-binding proteins that play an important role in packaging of heterochromatin and gene regulation. The functions of HP1 isoforms α and β...
3.
Krishnamoorthy V, Khanna R, Parnaik V
Biochim Biophys Acta Mol Cell Res
. 2018 May;
1865(8):1088-1104.
PMID: 29753763
Lamins constitute the major architectural proteins of the nuclear lamina that help in maintaining nuclear organization. Mutations in lamins are associated with diverse degenerative diseases, collectively termed laminopathies. HECW2, a...
4.
Khanna R, Krishnamoorthy V, Parnaik V
FEBS J
. 2018 Apr;
285(12):2243-2262.
PMID: 29676528
Lamins are key nuclear proteins which are important for maintaining nuclear structure and function. Mutations in lamins cause a spectrum of genetic diseases termed as laminopathies. RING finger containing E3...
5.
Raju R, Unnikrishnan M, Rubin D, Krishnamoorthy V, Kandror O, Akopian T, et al.
PLoS Pathog
. 2012 Feb;
8(2):e1002511.
PMID: 22359499
In most bacteria, Clp protease is a conserved, non-essential serine protease that regulates the response to various stresses. Mycobacteria, including Mycobacterium tuberculosis (Mtb) and Mycobacterium smegmatis, unlike most well studied...
6.
Wei J, Krishnamoorthy V, Murphy K, Kim J, Schnappinger D, Alber T, et al.
Proc Natl Acad Sci U S A
. 2011 Mar;
108(10):4176-81.
PMID: 21368134
It is often assumed that antibiotics act on the most vulnerable cellular targets, particularly those that require limited inhibition to block growth. To evaluate this assumption, we developed a genetic...
7.
Jakubowski S, Kerr J, Garza I, Krishnamoorthy V, Bayliss R, Waksman G, et al.
Mol Microbiol
. 2008 Dec;
71(3):779-94.
PMID: 19054325
Agrobacterium tumefaciens VirB10 couples inner membrane (IM) ATP energy consumption to substrate transfer through the VirB/D4 type IV secretion (T4S) channel and also mediates biogenesis of the virB-encoded T pilus....
8.
Christie P, Atmakuri K, Krishnamoorthy V, Jakubowski S, Cascales E
Annu Rev Microbiol
. 2005 Sep;
59:451-85.
PMID: 16153176
Type IV secretion (T4S) systems are ancestrally related to bacterial conjugation machines. These systems assemble as a translocation channel, and often also as a surface filament or protein adhesin, at...
9.
Jakubowski S, Cascales E, Krishnamoorthy V, Christie P
J Bacteriol
. 2005 May;
187(10):3486-95.
PMID: 15866936
Agrobacterium tumefaciens translocates DNA and protein substrates between cells via a type IV secretion system (T4SS) whose channel subunits include the VirD4 coupling protein, VirB11 ATPase, VirB6, VirB8, VirB2, and...
10.
Jakubowski S, Krishnamoorthy V, Cascales E, Christie P
J Mol Biol
. 2004 Aug;
341(4):961-77.
PMID: 15328612
The Agrobacterium tumefaciens VirB/D4 type IV secretion system (T4SS) translocates DNA and protein substrates across the bacterial cell envelope. Six presumptive channel subunits of this T4SS (VirD4, VirBll, VirB6, VirB8,...