Victor A Kostyuchenko
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Explore the profile of Victor A Kostyuchenko including associated specialties, affiliations and a list of published articles.
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37
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2822
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Recent Articles
1.
Kiewisz R, Fabig G, Conway W, Johnston J, Kostyuchenko V, Barinka C, et al.
bioRxiv
. 2025 Jan;
PMID: 39763817
It is now possible to generate large volumes of high-quality images of biomolecules at near-atomic resolution and in near-native states using cryogenic electron microscopy/electron tomography (Cryo-EM/ET). However, the precise annotation...
2.
Shu B, Ooi J, Tan A, Ng T, Dejnirattisai W, Mongkolsapaya J, et al.
Nat Commun
. 2022 Nov;
13(1):6756.
PMID: 36347841
Dengue virus infection can cause dengue hemorrhagic fever (DHF). Dengue NS1 is multifunctional. The intracellular dimeric NS1 (iNS1) forms part of the viral replication complex. Previous studies suggest the extracellular...
3.
Fibriansah G, Lim E, Marzinek J, Ng T, Tan J, Huber R, et al.
PLoS Pathog
. 2021 Feb;
17(2):e1009331.
PMID: 33621239
Different strains within a dengue serotype (DENV1-4) can have smooth, or "bumpy" surface morphologies with different antigenic characteristics at average body temperature (37°C). We determined the neutralizing properties of a...
4.
Zhou Q, Fox J, Earnest J, Ng T, Kim A, Fibriansah G, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(44):27637-27645.
PMID: 33087569
Chikungunya virus (CHIKV) is an emerging viral pathogen that causes both acute and chronic debilitating arthritis. Here, we describe the functional and structural basis as to how two anti-CHIKV monoclonal...
5.
Morrone S, Chew V, Lim X, Ng T, Kostyuchenko V, Zhang S, et al.
Nat Commun
. 2020 Jun;
11(1):3112.
PMID: 32561757
Previous flavivirus (dengue and Zika viruses) studies showed largely spherical particles either with smooth or bumpy surfaces. Here, we demonstrate flavivirus particles have high structural plasticity by the induction of...
6.
Zhang S, Loy T, Ng T, Lim X, Chew S, Tan T, et al.
Cell Rep
. 2020 Apr;
31(4):107584.
PMID: 32348755
Human antibody SIgN-3C neutralizes dengue virus (DENV) and Zika virus (ZIKV) differently. DENV:SIgN-3C Fab and ZIKV:SIgN-3C Fab cryoelectron microscopy (cryo-EM) complex structures show Fabs crosslink E protein dimers at extracellular...
7.
Tan T, Fibriansah G, Kostyuchenko V, Ng T, Lim X, Zhang S, et al.
Nat Commun
. 2020 Feb;
11(1):895.
PMID: 32060358
Structures of flavivirus (dengue virus and Zika virus) particles are known to near-atomic resolution and show detailed structure and arrangement of their surface proteins (E and prM in immature virus...
8.
Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody
Wirawan M, Fibriansah G, Marzinek J, Lim X, Ng T, Sim A, et al.
Structure
. 2018 Nov;
27(2):253-267.e8.
PMID: 30471923
Dengue virus (DENV) particles are released from cells in different maturation states. Fully immature DENV (immDENV) is generally non-infectious, but can become infectious when complexed with anti-precursor membrane (prM) protein...
9.
Zhang S, Kostyuchenko V, Ng T, Lim X, Ooi J, Lambert S, et al.
Nat Commun
. 2016 Nov;
7:13679.
PMID: 27882950
The rapid spread of Zika virus (ZIKV), which causes microcephaly and Guillain-Barré syndrome, signals an urgency to identify therapeutics. Recent efforts to rescreen dengue virus human antibodies for ZIKV cross-neutralization...
10.
Kostyuchenko V, Lim E, Zhang S, Fibriansah G, Ng T, Ooi J, et al.
Nature
. 2016 Apr;
533(7603):425-8.
PMID: 27093288
Zika virus (ZIKV), formerly a neglected pathogen, has recently been associated with microcephaly in fetuses, and with Guillian-Barré syndrome in adults. Here we present the 3.7 Å resolution cryo-electron microscopy...