Vickram Ramkumar
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Explore the profile of Vickram Ramkumar including associated specialties, affiliations and a list of published articles.
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51
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1828
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Recent Articles
1.
Al Aameri R, Alanisi E, Al Sallami D, Alberts I, Tischkau S, Rybak L, et al.
Front Immunol
. 2025 Mar;
16:1470625.
PMID: 40061942
Cisplatin is a chemotherapy drug used to treat different solid tumors, including ovarian, bladder, lung, and head and neck cancers. One of its significant side effects is ototoxicity, especially when...
2.
Rybak L, Alberts I, Patel S, Al Aameri R, Ramkumar V
Expert Opin Drug Metab Toxicol
. 2023 Sep;
19(9):635-652.
PMID: 37728555
Introduction: Cisplatin is a very effective chemotherapeutic agent against a variety of solid tumors. Unfortunately, cisplatin causes permanent sensorineural hearing loss in at least two-thirds of patients treated. There are...
3.
Al Aameri R, Alanisi E, Oluwatosin A, Al Sallami D, Sheth S, Alberts I, et al.
Front Immunol
. 2023 Apr;
14:1125948.
PMID: 37063917
Cisplatin is chemotherapy used for solid tumor treatment like lung, bladder, head and neck, ovarian and testicular cancers. However, cisplatin-induced ototoxicity limits the utility of this agent in cancer patients,...
4.
Ramkumar V, Mukherjea D, Dhukhwa A, Rybak L
Antioxidants (Basel)
. 2021 Dec;
10(12).
PMID: 34943021
Hearing loss is a significant health problem that can result from a variety of exogenous insults that generate oxidative stress and inflammation. This can produce cellular damage and impairment of...
5.
Ramkumar V, Sheth S, Dhukhwa A, Al Aameri R, Rybak L, Mukherjea D
Antioxid Redox Signal
. 2021 Sep;
36(16-18):1158-1170.
PMID: 34465184
Transient receptor potential (TRP) channels are cation-gated channels that serve as detectors of various sensory modalities, such as pain, heat, cold, and taste. These channels are expressed in the inner...
6.
Dhukhwa A, Al Aameri R, Sheth S, Mukherjea D, Rybak L, Ramkumar V
Sci Rep
. 2021 Apr;
11(1):8116.
PMID: 33854102
Regulators of G protein signaling (RGS) accelerate the GTPase activity of G proteins to enable rapid termination of the signals triggered by G protein-coupled receptors (GPCRs). Activation of several GPCRs,...
7.
Rybak L, Ramkumar V, Mukherjea D
Front Neurol
. 2021 Mar;
12:652674.
PMID: 33767665
It is well-known that aminoglycoside antibiotics can cause significant hearing loss and vestibular deficits that have been described in animal studies and in clinical reports. The purpose of this review...
8.
Rosati R, Shahab M, Ramkumar V, Jamesdaniel S
Mol Neurobiol
. 2021 Jan;
58(5):2019-2029.
PMID: 33411315
Cisplatin, a potent chemotherapeutic drug, induces ototoxicity, which limits its clinical utility. Cisplatin-induced oxidative stress plays a causal role in cochlear apoptosis while the consequent nitrative stress leads to the...
9.
Mukherjea D, Dhukhwa A, Sapra A, Bhandari P, Woolford K, Franke J, et al.
Expert Opin Drug Metab Toxicol
. 2020 Aug;
16(10):965-982.
PMID: 32757852
Introduction: Cisplatin is a highly effective chemotherapeutic agent against a variety of solid tumors in adults and in children. Unfortunately, a large percentage of patients suffer permanent sensorineural hearing loss....
10.
Targeting Inflammatory Processes Mediated by TRPVI and TNF-α for Treating Noise-Induced Hearing Loss
Dhukhwa A, Bhatta P, Sheth S, Korrapati K, Tieu C, Mamillapalli C, et al.
Front Cell Neurosci
. 2019 Oct;
13:444.
PMID: 31632242
Noise trauma is the most common cause of hearing loss in adults. There are no known FDA approved drugs for prevention or rescue of noise-induced hearing loss (NIHL). In this...