Alpha 2.0
Login Register
» Authors » Vera Richardson

Vera Richardson

Explore the profile of Vera Richardson including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 19
Citations 325
Followers 0
Related Specialties
Biochemistry
Chemistry
Oncology
Top 10 Co-Authors
Des R Richardson
Danuta S Kalinowski
Darius J R Lane
Angelica M Merlot
Zaklina Kovacevic
Mahendiran Dharmasivam
Mahan Gholam Azad
Sumit Sahni
Busra Kaya
Paul V Bernhardt
Published In
Oncotarget
PLoS One
J Med Chem
Biochim Biophys Acta
J Biol Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Innovative -Acridine Thiosemicarbazones and Their Zn(II) Complexes Transmetallate with Cu(II): Redox Activity and Suppression of Detrimental Oxy-Myoglobin Oxidation
Kaya B, Smith H, Chen Y, Azad M, Russell T, Richardson V, et al.
Inorg Chem . 2024 Oct; 63(43):20840-20858. PMID: 39404641
The coordination chemistry and electrochemistry of novel -acridine thiosemicarbazones (NATs) were investigated along with their redox activity, antiproliferative efficacy, transmetalation, and dissociation properties. The ability of NAT Fe(III) complexes to...
2.
Targeting lysosomes by design: novel -acridine thiosemicarbazones that enable direct detection of intracellular drug localization and overcome P-glycoprotein (Pgp)-mediated resistance
Kaya B, Smith H, Chen Y, Azad M, Russell T, Richardson V, et al.
Chem Sci . 2024 Aug; PMID: 39165729
Innovative -acridine thiosemicarbazones (NATs) were designed along with their iron(iii), copper(ii), and zinc(ii) complexes. Lysosomal targeting was promoted by specifically incorporating the lysosomotropic Pgp substrate, acridine, into the thiosemicarbazone scaffold...
3.
Isosteric Replacement of Sulfur to Selenium in a Thiosemicarbazone: Promotion of Zn(II) Complex Dissociation and Transmetalation to Augment Anticancer Efficacy
Kaya B, Azad M, Suleymanoglu M, Harmer J, Wijesinghe T, Richardson V, et al.
J Med Chem . 2024 Jul; 67(14):12155-12183. PMID: 38967641
We implemented isosteric replacement of sulfur to selenium in a novel thiosemicarbazone (PPTP4c4mT) to create a selenosemicarbazone (PPTP4c4mSe) that demonstrates potentiated anticancer efficacy and selectivity. Their design specifically incorporated cyclohexyl...
4.
Multi-modal mechanisms of the metastasis suppressor, NDRG1: Inhibition of WNT/β-catenin signaling by stabilization of protein kinase Cα
Azad M, Hussaini M, Russell T, Richardson V, Kaya B, Dharmasivam M, et al.
J Biol Chem . 2024 May; 300(7):107417. PMID: 38815861
The metastasis suppressor, N-myc downstream regulated gene-1 (NDRG1), inhibits pro-oncogenic signaling in pancreatic cancer (PC). This investigation dissected a novel mechanism induced by NDRG1 on WNT/β-catenin signaling in multiple PC...
5.
Differential transmetallation of complexes of the anti-cancer thiosemicarbazone, Dp4e4mT: effects on anti-proliferative efficacy, redox activity, oxy-myoglobin and oxy-hemoglobin oxidation
Dharmasivam M, Kaya B, Wijesinghe T, Richardson V, Harmer J, Gonzalvez M, et al.
Chem Sci . 2024 Jan; 15(3):974-990. PMID: 38239703
The di-2-pyridylthiosemicarbazone (DpT) analogs demonstrate potent and selective anti-proliferative activity against human tumors. The current investigation reports the synthesis and chemical and biological characterization of the Fe(iii), Co(iii), Ni(ii), Cu(ii),...
6.
The thiosemicarbazone, DpC, broadly synergizes with multiple anti-cancer therapeutics and demonstrates temperature- and energy-dependent uptake by tumor cells
Dharmasivam M, Azad M, Afroz R, Richardson V, Jansson P, Richardson D
Biochim Biophys Acta Gen Subj . 2022 Apr; 1866(8):130152. PMID: 35436509
Background: The di-2-pyridylketone thiosemicarbazones, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT) and di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), demonstrate potent and selective anti-tumor activity. In fact, DpC entered Phase I clinical trials for advanced and resistant tumors. Methods: This...
7.
Letter to the Editor: "Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques"
Merlot A, Sahni S, Lane D, Richardson V, Huang M, Kalinowski D, et al.
Int J Mol Sci . 2016 Nov; 17(11). PMID: 27854347
n/a.
8.
Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT)
Gutierrez E, Seebacher N, Arzuman L, Kovacevic Z, Lane D, Richardson V, et al.
Biochim Biophys Acta . 2016 Apr; 1863(7 Pt A):1665-81. PMID: 27102538
The potent and selective anti-tumor agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), localizes in lysosomes and forms cytotoxic copper complexes that generate reactive oxygen species (ROS), resulting in lysosomal membrane permeabilization (LMP) and...
9.
Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase
Merlot A, Shafie N, Yu Y, Richardson V, Jansson P, Sahni S, et al.
Biochem Pharmacol . 2016 Apr; 109:27-47. PMID: 27059255
The endoplasmic reticulum (ER) plays a major role in the synthesis, maturation and folding of proteins and is a critical calcium (Ca(2+)) reservoir. Cellular stresses lead to an overwhelming accumulation...
10.
The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets
Liu W, Kovacevic Z, Peng Z, Jin R, Wang P, Yue F, et al.
Oncotarget . 2015 Oct; 6(34):35522-41. PMID: 26431493
A major problem for cancer patients is the metastasis of cancer cells from the primary tumor. This involves: (1) migration through the basement membrane; (2) dissemination via the circulatory system;...