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» Authors » Venkata Ramana Vaka

Venkata Ramana Vaka

Explore the profile of Venkata Ramana Vaka including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 14
Citations 378
Followers 0
Related Specialties
Physiology
Biology
Cell Biology
Top 10 Co-Authors
Tarek Ibrahim
Babbette LaMarca
Lorena M Amaral
Denise C Cornelius
Mark W Cunningham Jr
Nathan Usry
Nathan Campbell
Mark W Cunningham
Evangeline Deer
Gerd Wallukat
Published In
Am J Physiol Regul Integr Comp Physiol
Pregnancy Hypertens
Hypertension
J Cell Mol Med
Biol Sex Differ
Affiliations
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Recent Articles
1.
The role of tumor necrosis factor in triggering activation of natural killer cell, multi-organ mitochondrial dysfunction and hypertension during pregnancy
Jayaram A, Deer E, Amaral L, Campbell N, Vaka V, Cunningham M, et al.
Pregnancy Hypertens . 2021 Mar; 24:65-72. PMID: 33677421
Pre-eclampsia (PE) is a hypertensive disorder of pregnancy associated with chronic inflammation, mitochondrial (mt) dysfunction and fetal demise. Natural Killer cells (NK cells) are critical for the innate immune response...
2.
Investigation of interleukin-2-mediated changes in blood pressure, fetal growth restriction, and innate immune activation in normal pregnant rats and in a preclinical rat model of preeclampsia
Cunningham Jr M, Amaral L, Campbell N, Cornelius D, Ibrahim T, Vaka V, et al.
Biol Sex Differ . 2021 Jan; 12(1):4. PMID: 33407826
Two important clinical features of preeclampsia (PE) are hypertension and fetal growth restriction. The reduced uterine perfusion pressure (RUPP) preclinical rat model of PE exhibits both of these features. Moreover,...
3.
CD4+ T cells cause renal and placental mitochondrial oxidative stress as mechanisms of hypertension in response to placental ischemia
Deer E, Reeve K, Amaral L, Vaka V, Franks M, Campbell N, et al.
Am J Physiol Renal Physiol . 2020 Nov; 320(1):F47-F54. PMID: 33196321
The reduced uterine perfusion pressure (RUPP) rat model and normal pregnant (NP) rat recipients of RUPP CD4+ T cells recapitulate many characteristics of preeclampsia such as hypertension and oxidative stress....
4.
17-Hydroxyprogesterone caproate improves hypertension and renal endothelin-1 in response to sFlt-1 induced hypertension in pregnant rats
Amaral L, Cottrell J, Comley K, Cunningham Jr M, Witcher A, Vaka V, et al.
Pregnancy Hypertens . 2020 Sep; 22:151-155. PMID: 32980622
Preeclampsia (PE) is characterized by new onset hypertension in association with elevated soluble fms-like tyrosine kinase-1 (sFlt-1) and preproendothelin-1 (PPET-1) levels. Currently there is no effective treatment for PE except...
5.
Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia
Cunningham M, Jayaram A, Deer E, Amaral L, Vaka V, Ibrahim T, et al.
Hypertens Pregnancy . 2020 Jul; 39(4):399-404. PMID: 32646252
Methods: On gestational day 14, RUPP surgery was performed, ETAN (0.4 mg/kg) was administered on day 18, MAP, blood and tissues collected on 19. Results: MAP, cytolytic NK cells and...
6.
Blockade of endogenous angiotensin II type I receptor agonistic autoantibody activity improves mitochondrial reactive oxygen species and hypertension in a rat model of preeclampsia
Vaka V, Cunningham M, Deer E, Franks M, Ibrahim T, Amaral L, et al.
Am J Physiol Regul Integr Comp Physiol . 2019 Nov; 318(2):R256-R262. PMID: 31721604
Preeclampsia (PE) is characterized by new-onset hypertension that usually occurs in the third trimester of pregnancy and is associated with oxidative stress and angiotensin II type 1 receptor agonistic autoantibodies...
7.
Renal natural killer cell activation and mitochondrial oxidative stress; new mechanisms in AT1-AA mediated hypertensive pregnancy
Cunningham Jr M, Vaka V, McMaster K, Ibrahim T, Cornelius D, Amaral L, et al.
Pregnancy Hypertens . 2019 Mar; 15:72-77. PMID: 30825931
Women with preeclampsia (PE) have increased mean arterial pressure (MAP), natural killer (NK) cells, reactive oxygen species (ROS), and agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA). AT1-AA's...
8.
Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in reduced uterine perfusion pressure rats
Vaka V, McMaster K, Cornelius D, Ibrahim T, Jayaram A, Usry N, et al.
Am J Physiol Regul Integr Comp Physiol . 2019 Feb; 316(5):R441-R447. PMID: 30811248
Preeclampsia (PE) is characterized by new-onset hypertension during pregnancy and is associated with immune activation and placental oxidative stress. Mitochondrial dysfunction is a major source of oxidative stress and may...
9.
Interleukin-4 supplementation improves the pathophysiology of hypertension in response to placental ischemia in RUPP rats
Cottrell J, Amaral L, Harmon A, Cornelius D, Cunningham Jr M, Vaka V, et al.
Am J Physiol Regul Integr Comp Physiol . 2019 Jan; 316(2):R165-R171. PMID: 30624978
Preeclampsia (PE) is characterized by chronic inflammation and elevated agonistic autoantibodies to the angiotensin type 1 receptor (AT-AA), endothelin-1, and uterine artery resistance index (UARI) during pregnancy. Previous studies report...
10.
Role of Mitochondrial Dysfunction and Reactive Oxygen Species in Mediating Hypertension in the Reduced Uterine Perfusion Pressure Rat Model of Preeclampsia
Vaka V, McMaster K, Cunningham Jr M, Ibrahim T, Hazlewood R, Usry N, et al.
Hypertension . 2018 Jul; 72(3):703-711. PMID: 30012871
Placental ischemia is believed to be the initial event in the development of preeclampsia. Mitochondrial dysfunction is a cause of reactive oxygen species (ROS) generation and oxidative stress, however, there...