Vellarkad N Viswanadhan
Overview
Explore the profile of Vellarkad N Viswanadhan including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
315
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Recent Articles
1.
Kristam R, Rao S, DCruz A, Mahadevan V, Viswanadhan V
J Mol Graph Model
. 2017 Jan;
72:112-128.
PMID: 28092830
Transient Receptor Potential Vanilloid, member 1 (TRPV1), is a non-selective cation channel belonging to the transient receptor potential (TRP) family of ion channels. It occurs in the peripheral and central...
2.
Kalindjian S, Kadnur S, Hewson C, Venkateshappa C, Juluri S, Kristam R, et al.
J Med Chem
. 2016 Mar;
59(7):3098-111.
PMID: 26987013
Chemokine receptor 9 (CCR9), a cell surface chemokine receptor which belongs to the G protein-coupled receptor, 7-trans-membrane superfamily, is expressed on lymphocytes in the circulation and is the key chemokine...
3.
Shanthi E, Krishna M, Arunesh G, Reddy K, Sooriya Kumar J, Viswanadhan V
Expert Opin Ther Pat
. 2014 Aug;
24(10):1077-100.
PMID: 25113248
Introduction: Focal adhesion kinase (FAK) plays a prominent role in integrin signaling. FAK activation increases phosphorylation of Tyr397 and other sites of the protein. FAK-dependent activation of signaling pathways implicated...
4.
Janardhan S, Seth S, Viswanadhan V
Mol Divers
. 2013 Oct;
18(1):161-81.
PMID: 24154731
P2X receptors are hetero-oligomeric proteins that function as membrane ion channels and are gated by extracellular ATP. The hP2X[Formula: see text] subunit is a constituent of the channels on a...
5.
Ajmani S, Viswanadhan V
Curr Comput Aided Drug Des
. 2013 Oct;
9(4):482-90.
PMID: 24138419
Receptor and non-receptor tyrosine kinases have emerged as clinically useful drug target for treating certain types of cancer. It is well known that tyrosine kinase inhibitors with multi-kinases inhibitory potency...
6.
Arunesh G, Shanthi E, Krishna M, Sooriya Kumar J, Viswanadhan V
Expert Opin Ther Pat
. 2013 Oct;
24(1):5-17.
PMID: 24131033
Introduction: The proviral insertion in murine (PIM) lymphoma proteins for which three isoforms, PIM1, PIM2 and PIM3 have been identified, belonging to the family of serine/threonine kinases has emerged recently...
7.
Mulakala C, Viswanadhan V
J Mol Graph Model
. 2013 Oct;
46:41-51.
PMID: 24121518
Implicit solvation methods such as MM-GBSA, when applied to evaluating protein/ligand binding free energies, are widely believed to be accurate only for the estimation of relative binding free energies for...
8.
Kristam R, Parmar V, Viswanadhan V
J Mol Graph Model
. 2013 Sep;
45:157-72.
PMID: 24036505
TRPV1 (Transient Receptor Potential Vanilloid Type 1) receptor, a member of Transient Receptor Potential Vanilloid subfamily of ion channels, occurs in the peripheral and central nervous system, and plays a...
9.
Kotasthane A, Mulakala C, Viswanadhan V
Proteins
. 2013 Sep;
82(3):436-51.
PMID: 23999908
The emerging picture of biomolecular recognition is that of conformational selection followed by induced-fit. Conformational selection theory states that binding partners exist in various conformations in solution, with binding involving...
10.
Ajmani S, Janardhan S, Viswanadhan V
Mol Divers
. 2013 Apr;
17(3):421-34.
PMID: 23612850
Gamma secretase (GS) is an appealing drug target for Alzheimer disease and cancer because of its central role in the processing of amyloid precursor protein and the notch family of...